About this Research Topic
Recent advances in CAR-T cell development are tackling these problems by offering novel solutions to increase specificity/efficiency and reduce the risk of side effects such as controllable adapter CAR platforms, suicide switches, dual CARs, gated CARs and novel combinations of CAR therapies with standard therapies e.g. small molecules, radiotherapy and/or chemotherapy.
In this Research Topic, we aim to collect articles on basic and translational research addressing emerging strategies to overcome current roadblocks in CAR-T cell immunotherapy. This Research Topic accepts Original Research, Methods, Review and Mini-Review, Clinical Trial, Perspective, Case Report, and Brief Research Reports. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Adapter CAR-T cells
• Novel CAR immune cells (NK, macrophages etc.)
• Overcoming the immunosuppressive tumor microenvironment
• Tackling the stem cell niche
• Improving CAR-T cell trafficking and tumor infiltration
• Novel combinations of CAR-T cell therapy and radio-/chemotherapy
• Combining CAR-T cells with other treatment modalities (e.g. small molecules,…)
• Combinatorial and gated targeting
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation are considered out of scope of this section.
Keywords: CAR T cells, adapter CARs, suicide switch, combined CAR-T cell therapies, gated CARs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.