Research Topic

The Mechanobiology of Glial Cells

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The ability of cells to respond to applied mechanical forces and interpret the signals mediated by the mechanical properties of their environment defines a phenomenon known as mechanotransduction, which plays an important role in cell behavior. Mechanical forces modulate several cellular functions including ...

The ability of cells to respond to applied mechanical forces and interpret the signals mediated by the mechanical properties of their environment defines a phenomenon known as mechanotransduction, which plays an important role in cell behavior. Mechanical forces modulate several cellular functions including proliferation, motility, morphogenesis and gene expression. Recent publications emerging from multiple laboratories have drawn attention to the importance of mechanotransduction in the development and function of myelinating glial cells. We think that this novel developing field will benefit from a timely collection of articles within this Research Topic.

This Research Topic will bring together different experimental approaches and model systems used to elucidate the role of mechanical forces in the development of glial cells in health and disease. Our aim is to include contributions covering all of the major types of glia in both the central (CNS) and peripheral (PNS) nervous systems (astrocytes, microglia, oligodendrocytes and Schwann cells), and the different processes they participate in during normal development and in pathological conditions.


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