Neurodegenerative diseases encompass a wide range of nervous system-related disorders, resulting from progressive damage to cells that are critical for cognition, movement, coordination, and sensation. They affect millions globally and have a significant impact on not only individuals, but their families, communities, and the economy. The ability of current clinical trial drugs to cross the blood-brain barrier and provide therapeutic relief is a major limitation, in addition to targeting unspecific mechanisms. Thus, many of these diseases remain incurable and lack effective treatments to slow their progression of the disease.
Recent advances in large-scale genomic technologies have revolutionized the field of biomedical science. We are rapidly moving towards simultaneously employing multiple approaches and exploring disease at single-cell resolutions. Bulk-level -omics have provided valuable insights into molecular pathways that may be altered during neurodegeneration. However, this can be difficult to interpret as they do not address the complexity of tissue composition and cellular heterogeneity. Single-cell approaches can help deconvolute the analytic complexity of individual cell types and cell states within a tissue and the relationship with various phenotypes. The overarching goal of this research topic is to further our understanding of single-cell genomes in the context of neurodegenerative disease.
As technology continues to evolve, we anticipate that the application of comprehensive multi-omic approaches combining genomics, transcriptomics, proteomics, metabolomics, and lipidomics will yield more precise and robust targets for therapeutic development.
We invite researchers in the field to submit Original Research Articles, Brief Reports, Methods, and Technology and Review Articles. With the rapid growth in technology, computational tools, and data generation in this field, we aim to create a repository of research on neurodegenerative diseases (dementias, Parkinsonism, MND/ALS, PSP, MSA, ataxias) within the scope of single-cell genomics as follows:
- Studies employing various cutting-edge single-cell or nuclei-omics approaches
- Integrative studies employing multi-omics approaches at single-cell resolution
- Novel computational analysis and modeling approaches applied to single-cell data
- Reviews addressing the status of the single cell -omics technology and research
Keywords:
Single Cell Genomics, Neurodegeneration
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Neurodegenerative diseases encompass a wide range of nervous system-related disorders, resulting from progressive damage to cells that are critical for cognition, movement, coordination, and sensation. They affect millions globally and have a significant impact on not only individuals, but their families, communities, and the economy. The ability of current clinical trial drugs to cross the blood-brain barrier and provide therapeutic relief is a major limitation, in addition to targeting unspecific mechanisms. Thus, many of these diseases remain incurable and lack effective treatments to slow their progression of the disease.
Recent advances in large-scale genomic technologies have revolutionized the field of biomedical science. We are rapidly moving towards simultaneously employing multiple approaches and exploring disease at single-cell resolutions. Bulk-level -omics have provided valuable insights into molecular pathways that may be altered during neurodegeneration. However, this can be difficult to interpret as they do not address the complexity of tissue composition and cellular heterogeneity. Single-cell approaches can help deconvolute the analytic complexity of individual cell types and cell states within a tissue and the relationship with various phenotypes. The overarching goal of this research topic is to further our understanding of single-cell genomes in the context of neurodegenerative disease.
As technology continues to evolve, we anticipate that the application of comprehensive multi-omic approaches combining genomics, transcriptomics, proteomics, metabolomics, and lipidomics will yield more precise and robust targets for therapeutic development.
We invite researchers in the field to submit Original Research Articles, Brief Reports, Methods, and Technology and Review Articles. With the rapid growth in technology, computational tools, and data generation in this field, we aim to create a repository of research on neurodegenerative diseases (dementias, Parkinsonism, MND/ALS, PSP, MSA, ataxias) within the scope of single-cell genomics as follows:
- Studies employing various cutting-edge single-cell or nuclei-omics approaches
- Integrative studies employing multi-omics approaches at single-cell resolution
- Novel computational analysis and modeling approaches applied to single-cell data
- Reviews addressing the status of the single cell -omics technology and research
Keywords:
Single Cell Genomics, Neurodegeneration
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.