Type 1 diabetes is a condition that currently has no cure, only palliative treatments such as insulin administration and, in some cases, pancreatic islet transplantation. Though it can develop at any age, it most commonly affects young children, especially those under five years old. Active research is focused on understanding the disease's pathogenesis, which could lead to more effective management strategies and potential prevention methods.
T1DM is an autoimmune disease. The study of the immunological mechanisms involved in the development of the disease at the cellular and host levels is essential. A body of epidemiological evidence, as well as experimental work, performed in vitro and in vivo in animal models, supports the role of viruses in the pathogenesis of T1DM. Viruses belonging to various families of viruses are likely to be involved, but it is mainly viruses of the Picornaviridae family, of the Enterovirus genus, in particular coxsackievirus B, that are the subject of the majority of studies.
The role of viruses in T1DM is strongly suspected but many questions remain open. Do viruses trigger or aggravate the disease? By what mechanisms are they likely to disrupt homeostasis leading to chronic pathology? The viral pathogenesis of T1DM is certainly the result of interactions between viral agents and the host.
These interactions involve the host's immune system, genetic background, and microbiota. Viruses may activate factors like endogenous retroviruses, triggering immunological processes with potentially harmful effects.
This Research Topic focuses on the immunological and virological aspects of Type 1 diabetes pathogenesis. We invite original articles and reviews that offer new insights into understanding and managing this chronic disease, which significantly impacts patients and has socio-economic implications.
We encourage submissions on topics including, but not limited to:
• Immunological aspects of Type 1 diabetes pathogenesis
• Viral influences on Type 1 diabetes
• Strategies to combat Type 1 diabetes by exploring its immunological and virological roots
Type 1 diabetes is a condition that currently has no cure, only palliative treatments such as insulin administration and, in some cases, pancreatic islet transplantation. Though it can develop at any age, it most commonly affects young children, especially those under five years old. Active research is focused on understanding the disease's pathogenesis, which could lead to more effective management strategies and potential prevention methods.
T1DM is an autoimmune disease. The study of the immunological mechanisms involved in the development of the disease at the cellular and host levels is essential. A body of epidemiological evidence, as well as experimental work, performed in vitro and in vivo in animal models, supports the role of viruses in the pathogenesis of T1DM. Viruses belonging to various families of viruses are likely to be involved, but it is mainly viruses of the Picornaviridae family, of the Enterovirus genus, in particular coxsackievirus B, that are the subject of the majority of studies.
The role of viruses in T1DM is strongly suspected but many questions remain open. Do viruses trigger or aggravate the disease? By what mechanisms are they likely to disrupt homeostasis leading to chronic pathology? The viral pathogenesis of T1DM is certainly the result of interactions between viral agents and the host.
These interactions involve the host's immune system, genetic background, and microbiota. Viruses may activate factors like endogenous retroviruses, triggering immunological processes with potentially harmful effects.
This Research Topic focuses on the immunological and virological aspects of Type 1 diabetes pathogenesis. We invite original articles and reviews that offer new insights into understanding and managing this chronic disease, which significantly impacts patients and has socio-economic implications.
We encourage submissions on topics including, but not limited to:
• Immunological aspects of Type 1 diabetes pathogenesis
• Viral influences on Type 1 diabetes
• Strategies to combat Type 1 diabetes by exploring its immunological and virological roots