Adequate energy and nutrition supply is the basis for the development, invasion and metastasis of malignant tumor cells. Abnormal energy metabolism is one of the most prominent characteristics of tumor cells. The field of tumor metabolism has developed from the discovery of the Warburg effect to the recent recognition of the complexity and diversity of tumor metabolism. Studies have indicated that abnormal tumor metabolism may play a key regulatory role in the multiple programmed death processes of tumor cells, which is closely related to the occurrence, development, metastasis and treatment of tumors. However, some questions remain on: (a)how tumor immune dysfunction or escape and tumor microenvironment induced by disorder of glyco-lipid metabolism affect the tumor occurrence, progression, metastasis and treatment through regulating programmed cell death; (b)how tumor treatment affects metabolism and programmed cell death; and so on. The application of new technologies makes it possible to find new mechanisms that affect programmed cell death in the process of tumor occurrence, progression, metastasis and treatment. In recent years, some important results have shown that the molecular targeted treatment for some tumors with abnormal metabolism may have potential prospects, but the underlying mechanism and significance between tumor metabolism and programmed cell death are not fully recognized.
This Research Topic focuses on the latest progress in tumor metabolism and programmed cell death, including the signal transduction and metabolic pathways that promote programmed cell death of tumors, the molecular mechanism of how tumor metabolites regulate tumor programmed cell death, how tumor cells maintain redox balance during tumor progression, the metabolic abnormalities of host and tumor microenvironment, and the new methods which are targeted on metabolism for tumor treatment.
We welcome Original Research, Reviews, and other accepted article types. Submissions may address, but are not limited to, the following:
• How metabolism regulates programmed cell death such as apoptosis, autophagy, pyroptosis, ferroptosis, and cuproptosis in tumors;
• The underlying molecular mechanism and significance of programmed cell death which is induced by abnormal metabolism in the treatment of tumors;
• Immune exhaustion and escape induced by abnormal metabolism leads to tumor microenvironment change and programmed cell death.
Adequate energy and nutrition supply is the basis for the development, invasion and metastasis of malignant tumor cells. Abnormal energy metabolism is one of the most prominent characteristics of tumor cells. The field of tumor metabolism has developed from the discovery of the Warburg effect to the recent recognition of the complexity and diversity of tumor metabolism. Studies have indicated that abnormal tumor metabolism may play a key regulatory role in the multiple programmed death processes of tumor cells, which is closely related to the occurrence, development, metastasis and treatment of tumors. However, some questions remain on: (a)how tumor immune dysfunction or escape and tumor microenvironment induced by disorder of glyco-lipid metabolism affect the tumor occurrence, progression, metastasis and treatment through regulating programmed cell death; (b)how tumor treatment affects metabolism and programmed cell death; and so on. The application of new technologies makes it possible to find new mechanisms that affect programmed cell death in the process of tumor occurrence, progression, metastasis and treatment. In recent years, some important results have shown that the molecular targeted treatment for some tumors with abnormal metabolism may have potential prospects, but the underlying mechanism and significance between tumor metabolism and programmed cell death are not fully recognized.
This Research Topic focuses on the latest progress in tumor metabolism and programmed cell death, including the signal transduction and metabolic pathways that promote programmed cell death of tumors, the molecular mechanism of how tumor metabolites regulate tumor programmed cell death, how tumor cells maintain redox balance during tumor progression, the metabolic abnormalities of host and tumor microenvironment, and the new methods which are targeted on metabolism for tumor treatment.
We welcome Original Research, Reviews, and other accepted article types. Submissions may address, but are not limited to, the following:
• How metabolism regulates programmed cell death such as apoptosis, autophagy, pyroptosis, ferroptosis, and cuproptosis in tumors;
• The underlying molecular mechanism and significance of programmed cell death which is induced by abnormal metabolism in the treatment of tumors;
• Immune exhaustion and escape induced by abnormal metabolism leads to tumor microenvironment change and programmed cell death.