According to the most recent projections of the International Agency for Research on Cancer (IARC), there would be around 19.3 million new cases of cancer and 10 million cancer-related deaths globally in 2022. Cancer research has never halted. In particular, research into the cancer immunological microenvironment is gaining popularity.
Immunotherapy, a novel cancer treatment, has shown promising early outcomes. Immunotherapy boosts survival for a range of solid cancers such as melanoma, and in certain individuals, it stimulates the immune system. However, there are still some challenges in immunotherapy including drug resistance and poor drug response. Numerous studies have indicated that the heterogeneity of cancer may play an important role in immunotherapy resistance. Therefore, more research into the immunological microenvironment of cancer is required to recognize various immune subtypes and to find new biomarkers to direct the treatment.
Transcriptome analysis and single-cell sequencing analysis are emerging strategies, which can analyze the gene expression level of individual cells in tissues to study the inter-cellular heterogeneity, distinguish cell types and subtypes, identify cell type-specific genes, and reveal cell dynamic processes.
This Research Topic aims to explore the immune microenvironment of cancer through transcriptome analysis and single-cell sequencing analysis, so as to provide references for precise treatment of cancer. We welcome the submission of Original Research and Review articles that include biomarkers in clinical studies and applications, as well as technologies or discoveries in experimental approaches. Potential subtopics include but are not limited to the following:
1. Transcriptome analysis, single-cell sequencing analysis, and other high-throughput approaches to define distinct immunological subtypes of cancer.
2. Transcriptome and single-cell sequencing studies that help discover new cancer prognostic markers, associated prognostic signatures, and immunotherapy prediction.
3. Investigating carcinogenicity of environmental disruptors, their potential detrimental influences on the human immune system, and crosstalk with cancer immunity.
4. Genetic vaccine for effective cancer treatment as a novel immune therapy.
5. Single-cell sequencing and spatial transcriptome analysis to clarify the spatial localization relationship between cells, and explore the potential immune mechanisms of tumors.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this section and will not be accepted as part of this Research Topic.
According to the most recent projections of the International Agency for Research on Cancer (IARC), there would be around 19.3 million new cases of cancer and 10 million cancer-related deaths globally in 2022. Cancer research has never halted. In particular, research into the cancer immunological microenvironment is gaining popularity.
Immunotherapy, a novel cancer treatment, has shown promising early outcomes. Immunotherapy boosts survival for a range of solid cancers such as melanoma, and in certain individuals, it stimulates the immune system. However, there are still some challenges in immunotherapy including drug resistance and poor drug response. Numerous studies have indicated that the heterogeneity of cancer may play an important role in immunotherapy resistance. Therefore, more research into the immunological microenvironment of cancer is required to recognize various immune subtypes and to find new biomarkers to direct the treatment.
Transcriptome analysis and single-cell sequencing analysis are emerging strategies, which can analyze the gene expression level of individual cells in tissues to study the inter-cellular heterogeneity, distinguish cell types and subtypes, identify cell type-specific genes, and reveal cell dynamic processes.
This Research Topic aims to explore the immune microenvironment of cancer through transcriptome analysis and single-cell sequencing analysis, so as to provide references for precise treatment of cancer. We welcome the submission of Original Research and Review articles that include biomarkers in clinical studies and applications, as well as technologies or discoveries in experimental approaches. Potential subtopics include but are not limited to the following:
1. Transcriptome analysis, single-cell sequencing analysis, and other high-throughput approaches to define distinct immunological subtypes of cancer.
2. Transcriptome and single-cell sequencing studies that help discover new cancer prognostic markers, associated prognostic signatures, and immunotherapy prediction.
3. Investigating carcinogenicity of environmental disruptors, their potential detrimental influences on the human immune system, and crosstalk with cancer immunity.
4. Genetic vaccine for effective cancer treatment as a novel immune therapy.
5. Single-cell sequencing and spatial transcriptome analysis to clarify the spatial localization relationship between cells, and explore the potential immune mechanisms of tumors.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this section and will not be accepted as part of this Research Topic.
