About this Research Topic
Recent advances in the past decades have revealed the possible pathophysiological mechanisms contributing to AKI such as inflammation, mitochondrial dysfunction, oxidative stress, metabolism, and altered gut microbiota, which help to identify new targets and pathways for novel therapies. The Research Topic aims to highlight the latest advancement in basic research to tackle the potential therapeutic strategies for AKI. The Research Topic will provide an update of new developments in a wide range of novel treatment approaches from gene therapy to pharmacological intervention, which will offer guidance on future directions in the discovery and development of promising therapeutic options with the transnational potential to improve outcomes for AKI patients.
This Research Topic welcomes Original Research Articles and Reviews addressing, but not limited to, the following themes:
-Mechanism of AKI
-The relationship between urinary calculi occurrence and renal inflammation
-New biomarkers for AKI diagnosis
-Novel pharmacological targets and pathways to treat AKI
-The association between AKI and DNA genetic polymorphism
-Advanced models and technologies to study AKI, including organoid culture
-Novel treatment methods of AKI such as stem cell-based therapy, non-pharmacological interventions and personalized therapy
-Development of new drug delivery systems for AKI treatment
-Sepsis-induced AKI
Keywords: acute kidney injury, repair, inflammation, metabolism, oxidative stress, mitochondrial dysfunction, gut microbiota, therapeutic targets
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.