Tumor microenvironment (TME) involves a variety of cellular and non-cellular components that play an essential role in the development of tumors. Many cell types, including stromal cells, fibroblasts, endothelial cells, lymphocytes, and myeloid cells, are recruited into the microenvironment of the developing gastrointestinal tumor and present multiple phenotypic and functional alterations. The interaction between tumor cells and the TME actively forms a tumor-supporting niche, leading to the occurrence, progression, metastasis, immune escape, and drug resistance of malignancies. Therefore, gastrointestinal tumor occurrence and progression are not only dependent on tumor cell reprogramming but also strongly influenced by TME. Identifying potential therapeutic targets and clarifying the regulatory mechanisms of new targets in the tumor microenvironment of the gastrointestinal tumor will all contribute to clinical treatment.
This Research Topic provides a forum to explore the potential therapeutic targets of the gastrointestinal tumor microenvironment. Our goal is to facilitate mechanism-based research into potential therapeutic targets by elucidating the mechanisms of the tumor microenvironment.
We welcome Original Research, Reviews, and Method articles focusing on subtopics including, but not limited to:
1. Molecular mechanisms involved in the interaction between tumor microenvironment and gastrointestinal tumor cells.
2. Epidemiologic evidence, bioinformatics analysis, and multi-omics research evidence of the relationship between immune and gastrointestinal tumors.
3. Development of potential therapeutic targets of the gastrointestinal tumor microenvironment, research of drug resistance mechanism, and strategies to overcome immunotherapy resistance.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Tumor microenvironment (TME) involves a variety of cellular and non-cellular components that play an essential role in the development of tumors. Many cell types, including stromal cells, fibroblasts, endothelial cells, lymphocytes, and myeloid cells, are recruited into the microenvironment of the developing gastrointestinal tumor and present multiple phenotypic and functional alterations. The interaction between tumor cells and the TME actively forms a tumor-supporting niche, leading to the occurrence, progression, metastasis, immune escape, and drug resistance of malignancies. Therefore, gastrointestinal tumor occurrence and progression are not only dependent on tumor cell reprogramming but also strongly influenced by TME. Identifying potential therapeutic targets and clarifying the regulatory mechanisms of new targets in the tumor microenvironment of the gastrointestinal tumor will all contribute to clinical treatment.
This Research Topic provides a forum to explore the potential therapeutic targets of the gastrointestinal tumor microenvironment. Our goal is to facilitate mechanism-based research into potential therapeutic targets by elucidating the mechanisms of the tumor microenvironment.
We welcome Original Research, Reviews, and Method articles focusing on subtopics including, but not limited to:
1. Molecular mechanisms involved in the interaction between tumor microenvironment and gastrointestinal tumor cells.
2. Epidemiologic evidence, bioinformatics analysis, and multi-omics research evidence of the relationship between immune and gastrointestinal tumors.
3. Development of potential therapeutic targets of the gastrointestinal tumor microenvironment, research of drug resistance mechanism, and strategies to overcome immunotherapy resistance.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
