Neuropsychiatric disorders are among the most burdensome diseases worldwide. Aside from conventional pharmaco- and psychotherapy, invasive as well as non-invasive stimulation methods including electroconvulsive therapy (ECT), transcranial magnetic and deep brain stimulation (TMS/DBS) have gained wider attention as valuable treatment options in recent years. This trend is rooted in their overall favorable risk-benefit profile, as they are safe and powerful tools in clinical practice, especially for certain disorders and specific subtypes. It is thus surprising that our knowledge concerning the underlying biological mechanisms that drive the clinical effects of these neurostimulation methods is limited. The latter is particularly true when it comes to different disease entities and states, disorder subtypes, and pre-treatment patient traits.
To advance our understanding of the biological effects that drive clinical improvement in different disorders and patients, novel research that brings clinical and preclinical expertise and methods together is key. Only in this way can the field move towards a better understanding and application of neurostimulation. The objective of this Research Topic is therefore to shed light on the intersection of basic, translational, and clinical neurostimulation research.
We encourage manuscripts featuring original data, meta-analyses, reviews, and case reports from the field of neuropsychiatry. We welcome the submission of novel ideas and innovative in vitro, in vivo, clinical, and computational approaches in the context of ECT, TMS, DBS, and other neurostimulation techniques. This includes, but is not limited to, research on affective and psychotic disorders, epilepsy, neurodegeneration, and neuroinflammation which fits one of the following topics:
• biobehavioral mechanisms (e.g., genetic, epigenetic, immunological, psychological) that drive, modulate, or prevent beneficial and/or side effects of neurostimulation
• stratification approaches for patient and/or disorder subtypes receiving neurostimulation to improve pre- and during-treatment prediction in day-to-day practice
• diagnostic and treatment biomarkers for neurostimulation in neuropsychiatry
• disorder- and/or disorder subtype-specific effects of different neurostimulation methods including biobehavioral similarities and differences between disorders and stimulation paradigms
• experimental or computational approaches that aim to improve basic neurostimulation research, its translation, and ultimately clinical benefits for neuropsychiatric patients.
Neuropsychiatric disorders are among the most burdensome diseases worldwide. Aside from conventional pharmaco- and psychotherapy, invasive as well as non-invasive stimulation methods including electroconvulsive therapy (ECT), transcranial magnetic and deep brain stimulation (TMS/DBS) have gained wider attention as valuable treatment options in recent years. This trend is rooted in their overall favorable risk-benefit profile, as they are safe and powerful tools in clinical practice, especially for certain disorders and specific subtypes. It is thus surprising that our knowledge concerning the underlying biological mechanisms that drive the clinical effects of these neurostimulation methods is limited. The latter is particularly true when it comes to different disease entities and states, disorder subtypes, and pre-treatment patient traits.
To advance our understanding of the biological effects that drive clinical improvement in different disorders and patients, novel research that brings clinical and preclinical expertise and methods together is key. Only in this way can the field move towards a better understanding and application of neurostimulation. The objective of this Research Topic is therefore to shed light on the intersection of basic, translational, and clinical neurostimulation research.
We encourage manuscripts featuring original data, meta-analyses, reviews, and case reports from the field of neuropsychiatry. We welcome the submission of novel ideas and innovative in vitro, in vivo, clinical, and computational approaches in the context of ECT, TMS, DBS, and other neurostimulation techniques. This includes, but is not limited to, research on affective and psychotic disorders, epilepsy, neurodegeneration, and neuroinflammation which fits one of the following topics:
• biobehavioral mechanisms (e.g., genetic, epigenetic, immunological, psychological) that drive, modulate, or prevent beneficial and/or side effects of neurostimulation
• stratification approaches for patient and/or disorder subtypes receiving neurostimulation to improve pre- and during-treatment prediction in day-to-day practice
• diagnostic and treatment biomarkers for neurostimulation in neuropsychiatry
• disorder- and/or disorder subtype-specific effects of different neurostimulation methods including biobehavioral similarities and differences between disorders and stimulation paradigms
• experimental or computational approaches that aim to improve basic neurostimulation research, its translation, and ultimately clinical benefits for neuropsychiatric patients.
