About this Research Topic
Additionally the repurposing of generic medications is appealing at a time when economic pressures are negatively impacting health systems globally. The potential for cheap generic medications to tackle cancer and other serious medical conditions in low and middle income countries is particularly appealing. The combination of drug repurposing and metronomic chemotherapy, often termed metronomics, is particularly appealing in this respect. However, more widespread adoption of the repurposing strategy is often hampered by a lack industry engagement and poor financial incentives. Therefore, while the advantages are clear, there are many challenges to overcome in order to show clinical efficacy, which is the most important criterion by which repurposing should be judged.
This Research Topic provides a focus on drug repurposing, particularly in a clinical context. Potential articles will focus on translational and clinical studies, case reports, trial rationales and so on. An additional focus will be on regulatory and institutional issues related to repurposing, including drug licensing, financial disincentives and other factors associated with translating trial results to clinical practice.
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