The kidney is a complex organ responsible for excretion of wastes, reabsorption of vital nutrients, acid-base homeostasis, maintenance of electrolyte-water balance, and hormone secretion. However, it is vulnerable to injury and the current treatment options for acute kidney injury and chronic kidney diseases are limited.
One potential approach is kidney regeneration, which is the capacity to regenerate renal tissue in response to injury. While neonephrogenesis, or the ability to regenerate renal tissue, is a distinctive feature of fish, evidence suggests that kidney repair can occur in mammals as well. Therefore, investigating whether terminally differentiated cells in adult animal kidneys have regenerative capacity and whether renal repair can be favored or accelerated by cells of extrarenal origin migrating to the kidney in response to injury is an important area of research.
To advance the understanding of renal repair and regeneration, we invite researchers to contribute their works to this Research Topic on kidney regeneration. The goal is to examine the cellular and molecular pathways related to renal repair and regeneration. Specifically, we encourage Original Research Articles, Brief Research Report, Reviews, and Perspectives that focus on the following areas:
• Tissue remodeling in renal fibrosis;
• Cells or reagents that benefit to kidney repair and its mechanisms;
• Cell fate determine in renal fibrosis and repair;
• In situ regeneration in kidney repair;
• Inflammation in renal fibrosis and kidney repair;
• Age related differences in kidney repair;
• Tissue engineering kidney development.
Keywords:
kidney injury, kidney regeneration, renal fibrosis, tissue remodeling, cell fate determinate, in situ regeneration
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The kidney is a complex organ responsible for excretion of wastes, reabsorption of vital nutrients, acid-base homeostasis, maintenance of electrolyte-water balance, and hormone secretion. However, it is vulnerable to injury and the current treatment options for acute kidney injury and chronic kidney diseases are limited.
One potential approach is kidney regeneration, which is the capacity to regenerate renal tissue in response to injury. While neonephrogenesis, or the ability to regenerate renal tissue, is a distinctive feature of fish, evidence suggests that kidney repair can occur in mammals as well. Therefore, investigating whether terminally differentiated cells in adult animal kidneys have regenerative capacity and whether renal repair can be favored or accelerated by cells of extrarenal origin migrating to the kidney in response to injury is an important area of research.
To advance the understanding of renal repair and regeneration, we invite researchers to contribute their works to this Research Topic on kidney regeneration. The goal is to examine the cellular and molecular pathways related to renal repair and regeneration. Specifically, we encourage Original Research Articles, Brief Research Report, Reviews, and Perspectives that focus on the following areas:
• Tissue remodeling in renal fibrosis;
• Cells or reagents that benefit to kidney repair and its mechanisms;
• Cell fate determine in renal fibrosis and repair;
• In situ regeneration in kidney repair;
• Inflammation in renal fibrosis and kidney repair;
• Age related differences in kidney repair;
• Tissue engineering kidney development.
Keywords:
kidney injury, kidney regeneration, renal fibrosis, tissue remodeling, cell fate determinate, in situ regeneration
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.