Maternal-Fetal Interface Formation and Pregnancy Outcome

72.5K

views

94

authors

16

articles

Maternal-Fetal Interface Formation and Pregnancy Outcome

72.5K

views

94

authors

16

articles

Editorial

25 February 2026

Editorial: Maternal-fetal interface formation and pregnancy outcome

Tao Cao

,

Zhengzhong Wu

and

Depeng Zhao

1,113 views

0 citations

Editors

3

Shenzhen Maternity and Child Healthcare Hospital

Federico Jensen

University of Buenos Aires

Oregon Health and Science University

Impact

About

The well-tuned formation of the maternal-fetal interface determines the quality of embryo implantation, placentation, fetal development and maternal well-being. Decidual cells, immune cells and trophoblasts compose the maternal-fetal interface and their interaction develops into the microenvironment. Recent studies focused on the maternal-fetal interface highlight the importance of this inadequately understood but significant tissue, e.g. the secretions from both decidual and immune cells regulate the function of trophoblasts. Therefore, deciphering the mechanisms underlying cell-cell interaction in the maternal-fetal interface would pave the way to improve treatment for implantation failure after embryo transfer and adverse pregnancy outcomes.

This Research Topic aims to emphasise the importance of collaborations between infertility physicians, embryologists and obstetricians to unravel the complex cell-cell interaction in the maternal-fetal interface and associated pregnancy prognosis.

We welcome submissions about, but not limited to:
• Molecular bases of interactome between trophoblasts, immune cells and decidual cells
• Mechanisms of trophoblast differentiation and invasion by cell-cell interaction at the maternal-fetal interface
• Application of deficient cell-cell interaction at the maternal-fetal interface to understanding early pregnancy loss and preeclampsia

The well-tuned formation of the maternal-fetal interface determines the quality of embryo implantation, placentation, fetal development and maternal well-being. Decidual cells, immune cells and trophoblasts compose the maternal-fetal interface and their interaction develops into the microenvironment. Recent studies focused on the maternal-fetal interface highlight the importance of this inadequately understood but significant tissue, e.g. the secretions from both decidual and immune cells regulate the function of trophoblasts. Therefore, deciphering the mechanisms underlying cell-cell interaction in the maternal-fetal interface would pave the way to improve treatment for implantation failure after embryo transfer and adverse pregnancy outcomes.

This Research Topic aims to emphasise the importance of collaborations between infertility physicians, embryologists and obstetricians to unravel the complex cell-cell interaction in the maternal-fetal interface and associated pregnancy prognosis.

We welcome submissions about, but not limited to:
• Molecular bases of interactome between trophoblasts, immune cells and decidual cells
• Mechanisms of trophoblast differentiation and invasion by cell-cell interaction at the maternal-fetal interface
• Application of deficient cell-cell interaction at the maternal-fetal interface to understanding early pregnancy loss and preeclampsia

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Editors

Shenzhen Maternity and Child Healthcare Hospital

Federico Jensen

University of Buenos Aires

Oregon Health and Science University

Impact

72,459 Total views

53,249 Article views

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1,642 Topic views

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Frontiers in Medicine

Obstetrics and Gynecology

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