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Hormones and Neural Aging: Lessons from Experimental Models

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The study of aging by using experimental models offers an opportunity to understand human physiopathology, which complements clinical and epidemiological studies.

The relationship between the hormonal status and neural aging has been studied in different contexts, from metabolism to reproduction. ...

The study of aging by using experimental models offers an opportunity to understand human physiopathology, which complements clinical and epidemiological studies.

The relationship between the hormonal status and neural aging has been studied in different contexts, from metabolism to reproduction. Neural aging is associated with modifications in the levels of different peripheral neuroprotective hormones, as it is also affected the sensitivity of neurons and glial cells to respond to peripheral metabolic signals. In turn, neural aging affects the control exerted by the hypothalamus on peripheral endocrine glands and body metabolism. Therefore, the feed-back loops between the brain and the body are progressively altered during the aging process, contributing to neural dysfunction.

Here, we propose to connect these studies with the current knowledge on the neurodegeneration of brain and sensory systems that takes place alongside aging. Molecular pathways implicated in the decreased cell renewal, cell senescence and cell death, as well as potential strategies to promote healthy brain aging and rejuvenation will be presented.


Keywords: Apoptosis, insulin-like factors, neurodegeneration, senescence, sex hormones


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