Metabolic reprogramming is a hallmark of cancer, and the carcinogenesis and progression of malignancies require metabolic reprogramming of tumor cells. Previous studies have revealed that tumor cells could autonomously alter their various metabolic pathways to meet the growing energy demands, and to alleviate the oxidative stress required for tumor cell proliferation and survival. In the past few decades, with the development and application of metabolomics technology (such as Nuclear Magnetic Resonance, Mass Spectrometry, and Spatial Metabolome), researchers have not only revealed tumor heterogeneity and plasticity, but also identified new metabolic pathways to maintain tumor growth. Metabolic abnormalities have also been proven to play a crucial role in the occurrence and development of gynecologic tumors (e.g., cervical cancer, endometrial carcinoma, ovarian cancer, etc.), but the exact role is not fully understood. This Research Topic attempts to summarize previous relevant research and collect cutting-edge studies related to dysregulated metabolism that focus on gynecologic tumors.
This Research Topic aims to identify pivotal dysregulated metabolites involved in the occurrence and progression of gynecologic malignancies, and further explore their potential functional mechanism. We wish to provide some novel insights for the treatment of gynecologic malignancies and prolong the prognosis of patients with gynecological malignancies.
The articles in the version of Systematic Review, Meta-analysis, Case Report, and Original Research are acceptable. Potential sub-topics are as below:
? Systematic review focusing on the research of dysregulated metabolites in gynecological malignancies
? Meta-analysis focusing on the research of dysregulated metabolites in gynecological malignancies
? Case report focusing on the rare and metabolic-related gynecological tumors
? Original Research focusing on the dysregulated metabolites and their functional mechanism on gynecological malignancies.
Metabolic reprogramming is a hallmark of cancer, and the carcinogenesis and progression of malignancies require metabolic reprogramming of tumor cells. Previous studies have revealed that tumor cells could autonomously alter their various metabolic pathways to meet the growing energy demands, and to alleviate the oxidative stress required for tumor cell proliferation and survival. In the past few decades, with the development and application of metabolomics technology (such as Nuclear Magnetic Resonance, Mass Spectrometry, and Spatial Metabolome), researchers have not only revealed tumor heterogeneity and plasticity, but also identified new metabolic pathways to maintain tumor growth. Metabolic abnormalities have also been proven to play a crucial role in the occurrence and development of gynecologic tumors (e.g., cervical cancer, endometrial carcinoma, ovarian cancer, etc.), but the exact role is not fully understood. This Research Topic attempts to summarize previous relevant research and collect cutting-edge studies related to dysregulated metabolism that focus on gynecologic tumors.
This Research Topic aims to identify pivotal dysregulated metabolites involved in the occurrence and progression of gynecologic malignancies, and further explore their potential functional mechanism. We wish to provide some novel insights for the treatment of gynecologic malignancies and prolong the prognosis of patients with gynecological malignancies.
The articles in the version of Systematic Review, Meta-analysis, Case Report, and Original Research are acceptable. Potential sub-topics are as below:
? Systematic review focusing on the research of dysregulated metabolites in gynecological malignancies
? Meta-analysis focusing on the research of dysregulated metabolites in gynecological malignancies
? Case report focusing on the rare and metabolic-related gynecological tumors
? Original Research focusing on the dysregulated metabolites and their functional mechanism on gynecological malignancies.