About this Research Topic
Cell invasion and migration are inherent characteristics of cancer cells irrespective of its type, and losing this function leads to cell arrest and eventually cell death. Defining the involved genes in invasion and metastasis is a diagnostic tool for determining the vital genes responsible for cell invasion and chemotaxis. Finding the main epigenetic alterations could elevate variations in the chemokines responsible for enhancing EMT status of cancer cells. Hence, we can determine the role of epigenetic alterations in cellular metastasis and investigate the targeting techniques that could decline epigenetic mutations and reduce the invasion and migration of cancer cells, together, with knocking down chemotactic gene markers responsible for elevating EMT processes responsible for metastatic pathways.
The goal of this Research Topic is to gather high-quality original research papers or reviews in themes including but not limited to:
1. Monitoring the fundamental assays required to profile epigenetic parameters that could be changed due to the developmental progression of cancer cells from epithelial to mesenchymal transition (EMT) states.
2. Evaluation of epigenetic alterations accomplishing EMT of different cancer types to transform cancer cells from the stable state to the invasive and migrating state, which consequently leads to metastasis.
3. Studying the correlation between the chemokine gene markers, responsible for invasion and migration, and epigenetic reversible changes in histones and/or DNA modifications, that decline DNA repair and activate EMT processes in cancer cells.
4. Monitoring the epigenetic gene markers underlying mechanistic pathways that trigger the transformation of cancer cells from the epithelial rest state to the mesenchymal mobile state.
5. Studying epigenetic alterations that contribute to EMT processes, histone acetylation, DNA methylation, and histone methylation that contribute to the transformation of cancer cells to enhance metastatic development.
The goal of this Research Topic is to gather high-quality original research papers or reviews in themes including but not limited to:
1. Monitoring the fundamental assays required to profile epigenetic parameters that could be changed due to the developmental progression of cancer cells from epithelial to mesenchymal transition (EMT) states.
2. Evaluation of epigenetic alterations accomplishing EMT of different cancer types to transform cancer cells from the stable state to the invasive and migrating state, which consequently leads to metastasis.
3. Studying the correlation between the chemokine gene markers, responsible for invasion and migration, and epigenetic reversible changes in histones and/or DNA modifications, that decline DNA repair and activate EMT processes in cancer cells.
4. Monitoring the epigenetic gene markers underlying mechanistic pathways that trigger the transformation of cancer cells from the epithelial rest state to the mesenchymal mobile state.
5. Studying epigenetic alterations that contribute to EMT processes, histone acetylation, DNA methylation, and histone methylation that contribute to the transformation of cancer cells to enhance metastatic development.
Keywords: epigenetics, metastasis, DNA methylation, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
