About this Research Topic
The goal of this research topic is to promote the understanding and translation aspect of EVs for therapeutic use in immunotherapy for cancer and other diseases, with the aim of gaining a better understanding of the greater application potential of EVs.
This Research Topic aims to cover novel research trends in the use of extracellular vesicles derived from effector immune cells, including engineered immune cells as novel immunotherapeutic approach to treat tumors as well as other disease. This Research Topic accepts Original Research, Methods, Review and Mini-Review, Clinical Trial, Classification, Study Protocol, Perspective, Case Report, Brief Research Report, Data Report, and Opinion articles. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Characterization of EVs derived from immune cells
• Immunoregulatory effects of EVs in immunotherapy
• Extracellular vesicles as immunosuppressive mediators in immunotherapy
• Intracellular communication between EVs and tumor microenvironments
• Tumor derived exosomes and their role in cancer initiation, host immune suppression, drug resistance and progression.
• Optimization and standardization of EVs isolation protocols
• Evaluation of therapeutic activity of EVs from different effector cells
• Comparison of therapeutic potential of EVs from different effector immune cells
• Clinical grade isolation of EVs for use in patients
Keywords: Extracellular vesicles, exosomes, Effector immune cells, CAR-T cells, Translational biotechnology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.