Exosomes are a type of extracellular vesicle that can be released by a majority of cells. They possess a lipid bilayer membrane structure and exhibit a diameter ranging from 50 to 150 nm. Exosomes contain a diverse array of cargos within their interior, including proteins, lipids, mRNA, non-coding RNA (such as miRNA, lncRNA, and tDRs), and metabolites.
In the context of tumor tissues, it has been reported that exosomes are released or taken up by various cell types, including but not limited to cancer cells, adipocytes, immune cells, and stromal cells. Hence, cargos derived from exosomes typically function as messengers that modulate the activity of signaling pathways within cells. Tumor cells can utilize exosomes as a means of conveying cargo to immune cells, thereby influencing the infiltration and activity of immune cells, ultimately leading to the establishment of an immunosuppressive microenvironment. Similarly, the exosomal cargo of immune cells has the potential to facilitate the growth and progression of tumor cells. Several exosome-derived cargos had been identified as biomarkers to predict immunotherapy resistance and patient prognosis. Interestingly, exosomes have been found to be a highly effective delivery system for exogenous cargos, including PDL1 inhibitors, facilitating targeted delivery to the desired site and promoting immune regulation.
The interest in exosome-derived cargo has been steadily growing over the years. The objective of this Research Topic was to ascertain the diagnostic significance of exosome-derived cargos in immune response, elucidate the effects and molecular mechanisms of exosome-derived cargos, and devise approaches to augment immunotherapy by utilizing exosomes as carriers of exogenous cargos.
This research theme aims to contribute to recent advances in the field of exosome-derived cargos, to survey trends in research related to exosome-derived cargos and immune microenvironments, and to suggest future directions in related fields. We welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, Methods, Perspectives, and Opinion articles focusing on, but not limited to, the following Subtopics:
1. The utilization of high-throughput sequencing on extensive population samples for the identification of novel exosome-derived cargos;
2. Clinical or bioinformatic analysis focused on diagnostic value and prognostic value of exosome-derived cargos;
3. Investigate the mechanisms of production of exosome-derived cargos and their effects on the immune environment;
4. Investigate the molecular mechanisms of novel exosome-derived cargos in regulating the immune cell function and their potential contribution to immunotherapy resistance;
5. Development of strategies for using exosomes to package exogenous cargos to promote immunotherapy.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Exosomes are a type of extracellular vesicle that can be released by a majority of cells. They possess a lipid bilayer membrane structure and exhibit a diameter ranging from 50 to 150 nm. Exosomes contain a diverse array of cargos within their interior, including proteins, lipids, mRNA, non-coding RNA (such as miRNA, lncRNA, and tDRs), and metabolites.
In the context of tumor tissues, it has been reported that exosomes are released or taken up by various cell types, including but not limited to cancer cells, adipocytes, immune cells, and stromal cells. Hence, cargos derived from exosomes typically function as messengers that modulate the activity of signaling pathways within cells. Tumor cells can utilize exosomes as a means of conveying cargo to immune cells, thereby influencing the infiltration and activity of immune cells, ultimately leading to the establishment of an immunosuppressive microenvironment. Similarly, the exosomal cargo of immune cells has the potential to facilitate the growth and progression of tumor cells. Several exosome-derived cargos had been identified as biomarkers to predict immunotherapy resistance and patient prognosis. Interestingly, exosomes have been found to be a highly effective delivery system for exogenous cargos, including PDL1 inhibitors, facilitating targeted delivery to the desired site and promoting immune regulation.
The interest in exosome-derived cargo has been steadily growing over the years. The objective of this Research Topic was to ascertain the diagnostic significance of exosome-derived cargos in immune response, elucidate the effects and molecular mechanisms of exosome-derived cargos, and devise approaches to augment immunotherapy by utilizing exosomes as carriers of exogenous cargos.
This research theme aims to contribute to recent advances in the field of exosome-derived cargos, to survey trends in research related to exosome-derived cargos and immune microenvironments, and to suggest future directions in related fields. We welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, Methods, Perspectives, and Opinion articles focusing on, but not limited to, the following Subtopics:
1. The utilization of high-throughput sequencing on extensive population samples for the identification of novel exosome-derived cargos;
2. Clinical or bioinformatic analysis focused on diagnostic value and prognostic value of exosome-derived cargos;
3. Investigate the mechanisms of production of exosome-derived cargos and their effects on the immune environment;
4. Investigate the molecular mechanisms of novel exosome-derived cargos in regulating the immune cell function and their potential contribution to immunotherapy resistance;
5. Development of strategies for using exosomes to package exogenous cargos to promote immunotherapy.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
