Research Topic

C1q: A Molecular Bridge to Innate and Adaptive Immunity

About this Research Topic

Like in most fields in science, the complement system is also in a fast gear of self-evolution, with new discoveries of unanticipated pathways and functions capable of cross-talk with other biologic systems. An emerging area that has been gaining much attention recently is the role of locally synthesized ...

Like in most fields in science, the complement system is also in a fast gear of self-evolution, with new discoveries of unanticipated pathways and functions capable of cross-talk with other biologic systems. An emerging area that has been gaining much attention recently is the role of locally synthesized complement proteins, which mediate a plethora of cellular functions thereby enhancing either health or disease. Prominent among the locally synthesized proteins is C1q, the first subcomponent of the complement classical pathway, which has been shown to regulate a wide range of immunological and pathological processes in autocrine or paracrine manners. Although the main source of the local synthesis of C1q has been attributed to the potent antigen presenting cells such as macrophages and dendritic cells, where it plays as a powerful molecular sensor of danger and regulator of self-tolerance, the list of the type of cells that locally synthesize C1q has been expanding over the years and now includes various types of proliferating and non-proliferating cells including malignant cells.

The aim of the current “Frontiers Topic” is, therefore, to compile a comprehensive list of review and research articles by experts in the field, so that they can be a major source of information for researchers and clinicians alike.


Keywords: complement, C1q, local synthesis, tolerance, pregnancy, tumour, complement independence, inflammation, receptors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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31 January 2018 Manuscript

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Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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