Genetic and Immunological Insights into Angioedema Without Wheals

Angioedema without wheals (AE) is a distinct clinical condition characterized by self-limiting and localized edema that occurs without the presence of urticaria. This condition manifests as swelling in various parts of the body, including the face, lips, tongue, larynx, abdomen, genitalia, or extremities. Unlike other forms of angioedema, AE does not respond to conventional treatments such as antihistamines and corticosteroids, necessitating interventions that primarily target the bradykinin pathways. The current challenge in the field is the frequent misdiagnosis of AE, leading to significant delays in appropriate treatment. This delay not only exacerbates the frequency and severity of attacks but also severely impacts the quality of life of patients, imposing a substantial economic burden. Recent studies have highlighted the critical need for accurate diagnosis and effective management strategies, especially given the life-threatening potential of laryngeal edema, which can result in asphyxiation if improperly treated. Despite advancements in understanding the pathogenesis of AE, there remain significant gaps in knowledge, particularly concerning the genetic and immunological underpinnings of the condition.

This research topic aims to explore the pathogenesis and diagnosis of angioedema without wheals, with the objective of uncovering the underlying mechanisms and improving patient management. The research will focus on addressing key questions such as the genetic factors contributing to AE, the identification of reliable biomarkers for diagnosis, and the development of effective treatment protocols. By testing hypotheses related to the immunological pathways involved in AE, this research seeks to enhance the understanding of the condition and provide a foundation for more accurate and timely diagnosis and treatment.

To gather further insights into the pathogenesis and diagnosis of angioedema without wheals, we welcome articles addressing, but not limited to, the following themes:
- Diagnosis and classification of angioedema without wheals
- Genetic factors and biomarkers associated with AE
- Treatment strategies targeting bradykinin pathways
- Epidemiological studies on the prevalence and impact of AE
- Quality of life assessments for patients with AE
- Challenging case reports or case series providing unique insights
- Immunological mechanisms underlying AE
- Advances in patient management and therapeutic interventions

Topic Editor Prof. Anastasios E Germenis is the co-founder of the spin-off company of the University of Thessaly CeMIA SA; The other Topic Editors declare no competing interests with regard to the Research Topic subject