About this Research Topic
This Research Topic aims to provide a state-of-the-art comprehensive collection of studies focusing on the various mechanisms enabling the modulation of synaptic formation and transmission in the mammalian CNS. We welcome the submission of original and review articles, opinion, hypothesis and perspective contributions for the current endeavor of analyzing the various levels of synaptic plasticity, synaptic scaling, spike-timing dependent plasticity and metaplasticity (both structural and functional), and their impact on network function and on the overall brain activity (e.g., during sleep). We foresee contributions with experimental approaches, including classic techniques (e.g., multi-cell patch clamp recordings), cutting-edge technologies (e.g., optical imaging and stimulation, and genetic tools), computer simulation and modeling approaches, as well as experimental-based hypotheses. The invited studies could span from molecular and cellular level of structural, dynamics and modulation of synaptic transmission up to neural network properties. The Topic includes neurogenesis and neural circuitries formation; neuronal-glial interactions; cell coupling; modulation of neurotransmitter release; neuropeptides and their functional roles; receptor types and dynamics and signal transduction; epigenetic modulation of synaptic transmission; dendritic spine structure and function; tetrapartite synapses; and synaptic modulation of behavioral display. Species of focus could range from rodents to non-human primates to human.
Keywords: synaptic formation and structure, neurotransmitter release, neuron-glia interaction, synaptic plasticity, neural circuit modulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.