Recent advances in novel nano-and microdevices containing nanostructures based on green technology and high biocompatibility can provide novel vehicles for environmentally sensitive biological molecules for industrial and therapeutic applications. Additionally, progress in molecular biology, genetics, and metabolic and genetic engineering has produced a large number of enzymes with high activity and purity from different natural kingdoms. However, the major challenges of enzyme use at industrial scale (e.g., biotransformations, foods, sensors, biomedicine, theragnostic and cosmeceuticals) are mainly due to the weak molecular structural characteristics and low enzyme stability. One strategy is the development of intra- or inter-crosslinked enzymes with enhanced stability that can be loaded into matrices for several applications of controlled-release systems. Enzyme encapsulation, entrapment, adsorption, or covalent attachment to nano- and microdevices could be excellent alternatives for industrial, environmental, and biomedical applications.
The main goal of the present Research Topic is to contribute to the state of the art of enzyme technology by the use of novel nano- and micro-devices correlated with the use of analytical techniques employed to solve the lack of enzyme industrial applications. In particular, the use of enzymes in biotransformations is mainly for the synthesis of chiral molecules (i.e., chemical precursors, antibiotics, anticancer drugs, antifungals, etc.) to replace chemical synthetic routes. Supplements in foods alleviate allergic pathologies and increase the digestibility of certain foods in people lacking certain digestive enzymes. Additionally, more than 100 enzymes can potentially be applied in many different therapies to reduce the undesirable side effects of drugs and increase therapeutic efficiency, but the lack of stability, high degradability, and lack of efficient catalytic activity make them unsuitable. Development of enzymatic sensors for use in diagnostic and theragnostic, environmental, and food quality applications requires of matrices able to keep the biocatalytic activity for extended periods. Recent advances in nano- and microdevices containing nanostructures, particularly in nanocomposites using natural and or biodegradable compounds, could create successful nano- and microstructures for enzyme protection and activity on a large scale.
We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Enzyme entrapment or encapsulation
• Enzyme immobilization in nano- and microdevices containing nanostructures.
• Enzyme delivery from matrices
• Kinetic models of enzyme release from nanodevices
• Therapeutic use of enzymes included in nano- and microdevices holding nanostructures.
• Biotransformation of molecules using nanodevices containing enzymes
• Application of biodegradable nanomatrices in foods
• Application of enzymes-nanodevices complexes in cosmeceuticals.
• Development of sensors enzyme based.
Keywords:
Enzymes, nanodevices, biotransformations, enzymatic sensors, therapeutic enzymes, enzymes in cosmeceuticals, enzymatic food supplements
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Recent advances in novel nano-and microdevices containing nanostructures based on green technology and high biocompatibility can provide novel vehicles for environmentally sensitive biological molecules for industrial and therapeutic applications. Additionally, progress in molecular biology, genetics, and metabolic and genetic engineering has produced a large number of enzymes with high activity and purity from different natural kingdoms. However, the major challenges of enzyme use at industrial scale (e.g., biotransformations, foods, sensors, biomedicine, theragnostic and cosmeceuticals) are mainly due to the weak molecular structural characteristics and low enzyme stability. One strategy is the development of intra- or inter-crosslinked enzymes with enhanced stability that can be loaded into matrices for several applications of controlled-release systems. Enzyme encapsulation, entrapment, adsorption, or covalent attachment to nano- and microdevices could be excellent alternatives for industrial, environmental, and biomedical applications.
The main goal of the present Research Topic is to contribute to the state of the art of enzyme technology by the use of novel nano- and micro-devices correlated with the use of analytical techniques employed to solve the lack of enzyme industrial applications. In particular, the use of enzymes in biotransformations is mainly for the synthesis of chiral molecules (i.e., chemical precursors, antibiotics, anticancer drugs, antifungals, etc.) to replace chemical synthetic routes. Supplements in foods alleviate allergic pathologies and increase the digestibility of certain foods in people lacking certain digestive enzymes. Additionally, more than 100 enzymes can potentially be applied in many different therapies to reduce the undesirable side effects of drugs and increase therapeutic efficiency, but the lack of stability, high degradability, and lack of efficient catalytic activity make them unsuitable. Development of enzymatic sensors for use in diagnostic and theragnostic, environmental, and food quality applications requires of matrices able to keep the biocatalytic activity for extended periods. Recent advances in nano- and microdevices containing nanostructures, particularly in nanocomposites using natural and or biodegradable compounds, could create successful nano- and microstructures for enzyme protection and activity on a large scale.
We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Enzyme entrapment or encapsulation
• Enzyme immobilization in nano- and microdevices containing nanostructures.
• Enzyme delivery from matrices
• Kinetic models of enzyme release from nanodevices
• Therapeutic use of enzymes included in nano- and microdevices holding nanostructures.
• Biotransformation of molecules using nanodevices containing enzymes
• Application of biodegradable nanomatrices in foods
• Application of enzymes-nanodevices complexes in cosmeceuticals.
• Development of sensors enzyme based.
Keywords:
Enzymes, nanodevices, biotransformations, enzymatic sensors, therapeutic enzymes, enzymes in cosmeceuticals, enzymatic food supplements
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.