About this Research Topic
The power of toxicogenomics lies within the ability to use genomic technologies in toxicology studies to better understand how chemicals and the environment affect public health. Over the years, basic science research, pharmaceutical efforts, clinical studies and regulatory activities have contributed enormously to the field of toxicogenomics. One of the challenges is how to incorporate ancillary toxicology or clinical data with genomics data from the studies as a function of time of exposure, dose, and tissue or cell type. The attainment of new knowledge about the effects of perturbations on biological systems may be possible through intuitive ways of integrating data.
Integration of data can take three forms: 1) physically combining the data for an analysis, 2) analyzing each data separately but in a way that supports each type or 3) analyzing each data separately and merging the results. In the end, the amalgamation of the data for analysis provides a more comprehensive deduction of the biological mechanisms and cellular functions associated with adverse outcomes from environmental exposures and toxicants. Thus, the objective of this Research Topic is to further our understanding of the biological consequences of environmental stressors and toxic insults through the unification of data.
This Research Topic is intended to focus on cutting-edge research and novel development efforts associated with the acquisition, use and analysis of integrated toxicogenomics data related to the following subject matter:
• Perturbed pathways elucidation (mode of action, gene regulatory networks, biological processes, etc.)
• Predicting human risk
• The Exposome and microbiome
• Genetical genomics and systems biology
• Analytical tools (biotechnology, software, computational, bioinformatics and statistical methodologies)
• Reference databases
The submission of manuscripts highlighting integrative toxicogenomics studies related diseased states or health afflictions is highly encouraged.
Keywords: Toxicogenomics, Environment, Data Integration, Exposure, Bioinformatics, Computational Biology, Genomics, Toxicology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.