About this Research Topic
Occupational exposure (wood and leather dust, textiles and organic solvents) has a causal role in the development of certain cancer types as well as non-occupational risk factors such as tobacco, nasal polyposis, inverted sinusal papilloma and radiation exposure.
The WHO classification of the sinonasal tract neoplasms has been updated in 2022 with the introduction of several new molecularly entities. The molecular profiling has been progressively integrated in the histopathologic classification of sinonasal carcinomas, with potential opportunities for the identification of cancers harboring actionable alterations.
The outcome of these rare malignancies is usually poor, with a huge variability according to histology and stage. Due to the rarity of these cancer types, evidence-based therapeutic strategies are lacking. Surgery represents the mainstay of treatment for small and localized cancers, while multimodality treatment is often required for locally advanced disease. Palliative chemo and/or radiotherapy is offered to patients with metastatic and recurrent disease not amenable to local treatment with curative intent. As well as the most common Head and Neck cancer, multidisciplinary management is required due to the complexity and heterogeneity of these very rare neoplasms.
The aim of the present article collection is to provide a comprehensive overview concerning these rare cancers ranging from epidemiology to treatment. Authors with different areas of expertise are invited to contribute to this article collection with original research, review articles, brief research report, general commentary and case reports.
Nasopharyngel cancer and salivary gland neoplasms of the sinonasal tract are out of the scope of this article collection and will not be accepted as part of this Research Topic. Also hematologic malignancies will not be considered for publication in this Research Topic.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: nasopharyngeal cancer, rare cancers, diagnosis, treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.