Gliomas, the most common primary brain tumors, continue to present formidable challenges to the field of oncology. These tumors arise from glial cells and exhibit aggressive growth, infiltrating adjacent brain tissues, making complete surgical resection often unattainable. Despite advancements in conventional therapies such as surgery, radiation, and chemotherapy, the overall prognosis for glioma patients remains disheartening. A major contributing factor to the dismal outcome of glioma treatment is the phenomenon of immune tolerance within the tumor microenvironment. Gliomas can harness an array of intricate mechanisms that effectively evade immune surveillance, allowing them to persist and progress unchecked by the host's immune system. These mechanisms involve the activation of immune checkpoint pathways, the recruitment and modulation of immunosuppressive cells, the secretion of immunosuppressive cytokines and chemokines, and alterations in the expression of specific genes that regulate immune responses. Understanding the diverse and dynamic interactions between glioma cells and the immune system is critical to developing targeted immunotherapies that can circumvent immune tolerance and elicit potent antitumor responses.
This Research Topic invites original research articles, reviews, and perspectives covering a wide range of topics related to the mechanisms of glioma immune tolerance in the context of the microenvironment. Potential areas of interest include, but are not limited to:
1. Immune Checkpoint Pathways: Investigating the role of immune checkpoint molecules, such as PD-1, CTLA-4, and others, in glioma immune tolerance
2. Tumor-Infiltrating Immunosuppressive Cells: Understanding the interactions and functions of regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and other immunosuppressive cell populations within the glioma microenvironment
3. Cytokine and Chemokine Profiling: exploring the secretion and impact of various cytokines and chemokines that mediate immunosuppression in gliomas
4. Genetic and Epigenetic Influences: Investigating genetic mutations and epigenetic alterations in glioma cells that contribute to immune escape mechanisms
5. Therapeutic Interventions: Presenting preclinical and clinical studies on immunotherapeutic approaches targeting glioma immune tolerance, including immune checkpoint inhibitors, adoptive T-cell therapies, and novel treatment modalities
Keywords:
glioma
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Gliomas, the most common primary brain tumors, continue to present formidable challenges to the field of oncology. These tumors arise from glial cells and exhibit aggressive growth, infiltrating adjacent brain tissues, making complete surgical resection often unattainable. Despite advancements in conventional therapies such as surgery, radiation, and chemotherapy, the overall prognosis for glioma patients remains disheartening. A major contributing factor to the dismal outcome of glioma treatment is the phenomenon of immune tolerance within the tumor microenvironment. Gliomas can harness an array of intricate mechanisms that effectively evade immune surveillance, allowing them to persist and progress unchecked by the host's immune system. These mechanisms involve the activation of immune checkpoint pathways, the recruitment and modulation of immunosuppressive cells, the secretion of immunosuppressive cytokines and chemokines, and alterations in the expression of specific genes that regulate immune responses. Understanding the diverse and dynamic interactions between glioma cells and the immune system is critical to developing targeted immunotherapies that can circumvent immune tolerance and elicit potent antitumor responses.
This Research Topic invites original research articles, reviews, and perspectives covering a wide range of topics related to the mechanisms of glioma immune tolerance in the context of the microenvironment. Potential areas of interest include, but are not limited to:
1. Immune Checkpoint Pathways: Investigating the role of immune checkpoint molecules, such as PD-1, CTLA-4, and others, in glioma immune tolerance
2. Tumor-Infiltrating Immunosuppressive Cells: Understanding the interactions and functions of regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and other immunosuppressive cell populations within the glioma microenvironment
3. Cytokine and Chemokine Profiling: exploring the secretion and impact of various cytokines and chemokines that mediate immunosuppression in gliomas
4. Genetic and Epigenetic Influences: Investigating genetic mutations and epigenetic alterations in glioma cells that contribute to immune escape mechanisms
5. Therapeutic Interventions: Presenting preclinical and clinical studies on immunotherapeutic approaches targeting glioma immune tolerance, including immune checkpoint inhibitors, adoptive T-cell therapies, and novel treatment modalities
Keywords:
glioma
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.