Diabetes mellitus (DM) can have a range of impacts on the nervous system and can lead to a decrease in multiple domains of cognitive function which range from small decrements in function to dementia. Cognitive impairment as a comorbidity of diabetes is multifactorial and dysfunction in one pathway can lead to discordance in metabolic signaling. These mechanisms can be related to mitochondrial dysfunction, insulin signaling dysfunction, and endothelial dysfunction, amongst others.
These defects have been associated with various structural and functional changes in the brain which can be identified using neuroimaging technology on patients. Some of these changes include interhemispheric asymmetry, peculiarities of vascularization and brain hypo- connectivity. Complications associated with pathology of the central nervous system are expected to increase due to the prevalence of type 2 diabetes mellitus and increasing life expectancy of populations across the World. This may have significant impacts on public health in the future.
This research topic aims to focus on several aspects of the connections between diabetes and cognition impairment in both animal and human models. We will present new advances in analysis of structural, metabolic and neurovascularization changes in the brain of patients with DM. This will build towards the goal of improving identification of cognitive impairment in patients with DM and to identify patients at risk of dementia or other forms of severe cognitive impairment. We will also include investigations of the maintenance of health behaviours for those with DM in the context of prevention of cognitive disorders.
We welcome submissions of original research, review and mini-review on the sub-topics below regarding relationships between DM and cognitive disorders:
- The role of diabetes in the aetiology and development of cognitive impairment
- Identification of cognitive impairment and associated neural substrates in patients with DM
- Maintenance of health behaviours in the context of prevention of cognitive disorders and endocrine risk factors.
Diabetes mellitus (DM) can have a range of impacts on the nervous system and can lead to a decrease in multiple domains of cognitive function which range from small decrements in function to dementia. Cognitive impairment as a comorbidity of diabetes is multifactorial and dysfunction in one pathway can lead to discordance in metabolic signaling. These mechanisms can be related to mitochondrial dysfunction, insulin signaling dysfunction, and endothelial dysfunction, amongst others.
These defects have been associated with various structural and functional changes in the brain which can be identified using neuroimaging technology on patients. Some of these changes include interhemispheric asymmetry, peculiarities of vascularization and brain hypo- connectivity. Complications associated with pathology of the central nervous system are expected to increase due to the prevalence of type 2 diabetes mellitus and increasing life expectancy of populations across the World. This may have significant impacts on public health in the future.
This research topic aims to focus on several aspects of the connections between diabetes and cognition impairment in both animal and human models. We will present new advances in analysis of structural, metabolic and neurovascularization changes in the brain of patients with DM. This will build towards the goal of improving identification of cognitive impairment in patients with DM and to identify patients at risk of dementia or other forms of severe cognitive impairment. We will also include investigations of the maintenance of health behaviours for those with DM in the context of prevention of cognitive disorders.
We welcome submissions of original research, review and mini-review on the sub-topics below regarding relationships between DM and cognitive disorders:
- The role of diabetes in the aetiology and development of cognitive impairment
- Identification of cognitive impairment and associated neural substrates in patients with DM
- Maintenance of health behaviours in the context of prevention of cognitive disorders and endocrine risk factors.