Research Topic

Tuning Metabolic Efficiency Through Flavin-based Electron Bifurcation

About this Research Topic

This Research Topic will include review and original research papers dealing with the biochemical properties and physiological implications of enzymes that catalyze flavin-based electron bifurcation. Flavin-based electron bifurcation is a fairly recently realized biochemical phenomenon through which endergonic and exergonic oxidation reduction reactions are effectively coupled to yield metabolically favorable reactions with minimal free energy changes. Thus far flavin-based electron bifurcation has been realized to be associated with anaerobic metabolism and nitrogen fixation and implicated to be key in remodeling chemical energy and reductant pools in cells to maximize energy efficiency. Recent work on the biochemistry of enzymes that catalyze flavin-based electron bifurcation reveal new paradigms for oxidation reduction based catalysts including expanding the oxidation reduction range of light independent biochemical processes.

The Research Topic will highlight aspects of the physiological roles and specific reactions catalyzed, evolution, and recent insights into the biochemical and catalytic properties.


Keywords: electron bifurcation, electron transfer, bioenergetics, flavin adenine dinucleotide, iron-sulfur clusters


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

This Research Topic will include review and original research papers dealing with the biochemical properties and physiological implications of enzymes that catalyze flavin-based electron bifurcation. Flavin-based electron bifurcation is a fairly recently realized biochemical phenomenon through which endergonic and exergonic oxidation reduction reactions are effectively coupled to yield metabolically favorable reactions with minimal free energy changes. Thus far flavin-based electron bifurcation has been realized to be associated with anaerobic metabolism and nitrogen fixation and implicated to be key in remodeling chemical energy and reductant pools in cells to maximize energy efficiency. Recent work on the biochemistry of enzymes that catalyze flavin-based electron bifurcation reveal new paradigms for oxidation reduction based catalysts including expanding the oxidation reduction range of light independent biochemical processes.

The Research Topic will highlight aspects of the physiological roles and specific reactions catalyzed, evolution, and recent insights into the biochemical and catalytic properties.


Keywords: electron bifurcation, electron transfer, bioenergetics, flavin adenine dinucleotide, iron-sulfur clusters


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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