Hepatocellular Carcinoma: Novel Treatment Strategies, volume III

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Hepatocellular Carcinoma: Novel Treatment Strategies, volume III

63.4K

views

138

authors

20

articles

Editorial

23 September 2025

Editorial: Hepatocellular carcinoma: novel treatment strategies, volume III

Fan Feng

and

Xiaojie Xu

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1 citations

Editors

5

Fan Feng

The 302th Hospital of PLA

Yinying Lu

Comprehensive Liver Cancer Department, Fifth Medical Center of the PLA General Hospital

Andrea Casadei Gardini

Vita-Salute San Raffaele University

Xiaojie Xu

Beijing Institute of Technology

Dechun Feng

National Institute on Alcohol Abuse and Alcoholism (NIH)

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This Research Topic is part of the series of "Hepatocellular Carcinoma: Novel Treatment Strategies":
Hepatocellular Carcinoma: Novel Treatment Strategies - Volume I
Hepatocellular Carcinoma: Novel Treatment Strategies - Volume II

Building on the foundational knowledge established about Tyrosine Kinase Inhibitors (TKIs) in Volumes I and II, Volume III will expand the scope also to Immune Checkpoint Inhibitors (ICIs). We will delve deeper into innovative therapeutic approaches for managing Hepatocellular Carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) against their respective challenges.

HCC not only seriously endangers the physical and mental health of patients, but also poses a significant challenge to public health. The majority of patients diagnosed with advanced HCC are not eligible to receive radical treatment, such as surgery, targeted molecular therapy (i.e. oral protein kinase inhibitors) or precision chemotherapy (i.e. transarterial chemoembolization or the long-acting sustained-release formulation of antitumor agents) is the main therapeutic strategy effective for advanced HCC.

Although molecular targeted drugs, such as Sorafenib, can delay the progression of HCC disease and prolong patient survival, they still present a number of challenges: (1) Sorafenib treatment in advanced HCC patients. There are individual differences in the initial sensitivity of patients to Sorafenib, and most patients who initially respond well to Sorafenib will eventually develop drug tolerance as the treatment progresses; (2) Existing treatment strategies (e.g. Sorafenib treatment requires oral high-dose of [800mg per day]) can cause serious side effects while treating cancer; (3) Recently, Lenvatinib has been approved as a first-line therapy, and Regorafenib as a second-line therapy, with the hope that there may be further reports reviewing their tolerance in the future. (4) HCC-targeted drug therapy remains costly. (5) Some novel agents, including Donafeinib, Regorafenib, Lenvatinib, and Carbozantinib have similar Physiological mechanisms, and share similar chemical structures unit with sorafenib: all these compounds are built based on the skeleton structure of 1-(4-(pyridin-4-yloxy)phenyl)urea.

In this Research Topic, we aim to provide an overview of the recent progress around HCC treatment, especially HCC-ICC-related drug therapy and the molecular mechanism of drug resistance (not only for TKIs, but also for ICIs), encompassing relevant basic and translational studies.

We welcome submission of Original Research, Mini Review and Review articles focusing on the sub-topics below:
• Molecular mechanisms related to the HCC or ICC, i.e. the molecular mechanism of antitumor drug resistance, proliferation or metastasis
• Small molecule kinase inhibitors or chemotherapeutic drugs with new structures for HCC or ICC treatment
• New long-acting and sustained-release anti-tumor drugs on HCC or ICC, including chemotherapy, TKIs and ICIs
• Nanomedicine and materials for HCC or ICC treatment
• Molecular markers based on novel clinical laboratory technology
• HCC, ICC-related metabolic, metabolomics studies
• Progress in intrahepatic cholangiocarcinoma treatment and research
• Clinical application of surgical robots
• HCC, ICC-related organoid studies

Please note: manuscripts submitted consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.

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Editors

Fan Feng

The 302th Hospital of PLA

Yinying Lu

Comprehensive Liver Cancer Department, Fifth Medical Center of the PLA General Hospital

Andrea Casadei Gardini

Vita-Salute San Raffaele University

Xiaojie Xu

Beijing Institute of Technology

Dechun Feng

National Institute on Alcohol Abuse and Alcoholism (NIH)

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Published In

Frontiers in Medicine

Translational Medicine

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Frontiers in Oncology

Cancer Immunity and Immunotherapy, Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

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