Cancer ranks as a leading cause of death and represents a prominent barrier to longevity in every country across the world. A hallmark of cancer is the immuno-inflammatory response, which plays a dual role in tumorigenesis. Studies have shown that immuno-inflammatory response can modulate cancer development in various ways, including by the form of the tumor microenvironment, by the regulation of cell proliferation, and by the secretion of cytokines. Due to the Janus-faced nature, immuno-inflammatory response has even been proposed as a unifying link between factors that cause and prevent cancer. Immunity-boosting agents are all the rage right now, while anti-inflammatory drugs have also been proposed and evaluated continuously over the decades as a means of cancer therapy. These contradictory effects require researchers to dig deeper into the anticancer conditions of immuno-inflammatory responses.
Oxidative stress is a reaction process posed by the accumulation of free radicals. Although drastic oxidative stress boosts cell death and severe cellular damage, certain oxidative damage are critical contributors to the occurrence and development of cancer. Oxidative stress can be triggered by environmental changes such as inflammation, while it can in turn cause irritation, resulting in a chronic inflammatory situation. Notably, the tumor itself, as well as many components of the tumor microenvironment, can produce a variety of inflammatory mediators and reactive oxygen species, thus forming chronic oxidative stress and chronic inflammatory environments, which are known to suppress the cell-mediated immune system. Collectively, immuno-inflammatory response, oxidative stress, and tumorgenesis are intricately intertwined and fuelled by each other. To date, there are deficient biomarkers for better understanding these interactions in cancer pathogenesis.
This Research Topic aims to put a spotlight on the recent advances and to suggest future directions in the crosstalk between immuno-inflammatory response and oxidative stress in cancer pathogenesis and cancer therapy. We encourage the submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, Perspectives, Methods, and Opinion articles centered on, but not limited to, the following topics:
- New insights into the interplay between immuno-inflammatory response and oxidative stress in the pathogenesis of cancer and/or inflammatory disease.
- The mutual and distinct impact of immunoreaction and inflammatory response on the occurrence and development of cancer.
- Biomarkers regarding immuno-inflammatory response and/or oxidative stress for cancer management.
- The Janus-faced role of immuno-inflammatory response and/or oxidative stress in tumorigenesis.
- Emerging therapeutic strategies targeting the players of oxidative stress or inflammatory immune response in cancer treatment.
- The crosstalk between different immune inflammatory cells and tumor cells.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Cancer ranks as a leading cause of death and represents a prominent barrier to longevity in every country across the world. A hallmark of cancer is the immuno-inflammatory response, which plays a dual role in tumorigenesis. Studies have shown that immuno-inflammatory response can modulate cancer development in various ways, including by the form of the tumor microenvironment, by the regulation of cell proliferation, and by the secretion of cytokines. Due to the Janus-faced nature, immuno-inflammatory response has even been proposed as a unifying link between factors that cause and prevent cancer. Immunity-boosting agents are all the rage right now, while anti-inflammatory drugs have also been proposed and evaluated continuously over the decades as a means of cancer therapy. These contradictory effects require researchers to dig deeper into the anticancer conditions of immuno-inflammatory responses.
Oxidative stress is a reaction process posed by the accumulation of free radicals. Although drastic oxidative stress boosts cell death and severe cellular damage, certain oxidative damage are critical contributors to the occurrence and development of cancer. Oxidative stress can be triggered by environmental changes such as inflammation, while it can in turn cause irritation, resulting in a chronic inflammatory situation. Notably, the tumor itself, as well as many components of the tumor microenvironment, can produce a variety of inflammatory mediators and reactive oxygen species, thus forming chronic oxidative stress and chronic inflammatory environments, which are known to suppress the cell-mediated immune system. Collectively, immuno-inflammatory response, oxidative stress, and tumorgenesis are intricately intertwined and fuelled by each other. To date, there are deficient biomarkers for better understanding these interactions in cancer pathogenesis.
This Research Topic aims to put a spotlight on the recent advances and to suggest future directions in the crosstalk between immuno-inflammatory response and oxidative stress in cancer pathogenesis and cancer therapy. We encourage the submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, Perspectives, Methods, and Opinion articles centered on, but not limited to, the following topics:
- New insights into the interplay between immuno-inflammatory response and oxidative stress in the pathogenesis of cancer and/or inflammatory disease.
- The mutual and distinct impact of immunoreaction and inflammatory response on the occurrence and development of cancer.
- Biomarkers regarding immuno-inflammatory response and/or oxidative stress for cancer management.
- The Janus-faced role of immuno-inflammatory response and/or oxidative stress in tumorigenesis.
- Emerging therapeutic strategies targeting the players of oxidative stress or inflammatory immune response in cancer treatment.
- The crosstalk between different immune inflammatory cells and tumor cells.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
