The human body contains complex microbiome communities that contain the entire genomes of different communities of microorganisms. The human virome is predominated by bacteriophages but also includes archaeal and eukaryotic viruses that are mainly located in the gastrointestinal tract, but also in the oral cavity, respiratory tract, blood, or skin, among others. Recent evidence suggests that the gut virome seems to play a key role in maintaining a healthy and balanced gut microbiome. However, the human virome has also been reported to be associated with different gastrointestinal, liver, and metabolic disorders such as Inflammatory Bowel Disease (IBD), colorectal cancer, metabolic dysfunction-associated steatotic liver disease (MASLD), type 1 diabetes, type 2 diabetes, and obesity, although the underlying pathogenic mechanisms are still not clearly understood. Viruses are very common and biodiverse microorganisms worldwide and the human virome is similarly complex and intricate. It is important to reveal the role and effect of the human virome in the etiology and pathophysiology of these disorders. Hence, a better understanding of the mechanisms governing the constituents of the human virome, and their shifts during health and disease is needed.
The aim of this Research Topic is to provide an up-to-date summary of recent findings on the role and the relationship of the human virome with gastrointestinal, liver, and metabolic disorders. This Research Topic will act as a key initiative towards facilitating a discussion on the role of virome located in the gut, mouth, respiratory tract, blood, skin, and other human body parts and its interactions with the immune system in these disorders.
The following article types will be accepted: Original Research, Clinical Trials, Reviews, Systematic reviews, Brief Research Reports, Case Reports, Mini-reviews, Perspectives, General commentaries, and Opinions. The following themes are welcome:
• Studies connecting the human virome in gastrointestinal, liver, and metabolic disorders
• Studies analyzing the human virome composition and functional variation among gastrointestinal, liver, and metabolic disorders
• Unravelling the role of the human virome in gastrointestinal, liver, and metabolic disorder etiology, physiology, and its response to medications and clinical procedures
• Studies connecting the human virome-immune homeostasis and regulation of the immune response in gastrointestinal, liver, and metabolic disorders
• Studies analyzing the human virome interventions, including fecal microbiota transplantation, diet, supplements, clinical trials, or therapies in gastrointestinal, liver, and metabolic disorders
Keywords:
human virome, gut virome, obesity, diabetes mellitus, immune response, pathogenesis, pathophysiology, mechanisms, gastrointestinal disease, liver disease, metabolic disorder, IBD, colorectal cancer, MASLD
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The human body contains complex microbiome communities that contain the entire genomes of different communities of microorganisms. The human virome is predominated by bacteriophages but also includes archaeal and eukaryotic viruses that are mainly located in the gastrointestinal tract, but also in the oral cavity, respiratory tract, blood, or skin, among others. Recent evidence suggests that the gut virome seems to play a key role in maintaining a healthy and balanced gut microbiome. However, the human virome has also been reported to be associated with different gastrointestinal, liver, and metabolic disorders such as Inflammatory Bowel Disease (IBD), colorectal cancer, metabolic dysfunction-associated steatotic liver disease (MASLD), type 1 diabetes, type 2 diabetes, and obesity, although the underlying pathogenic mechanisms are still not clearly understood. Viruses are very common and biodiverse microorganisms worldwide and the human virome is similarly complex and intricate. It is important to reveal the role and effect of the human virome in the etiology and pathophysiology of these disorders. Hence, a better understanding of the mechanisms governing the constituents of the human virome, and their shifts during health and disease is needed.
The aim of this Research Topic is to provide an up-to-date summary of recent findings on the role and the relationship of the human virome with gastrointestinal, liver, and metabolic disorders. This Research Topic will act as a key initiative towards facilitating a discussion on the role of virome located in the gut, mouth, respiratory tract, blood, skin, and other human body parts and its interactions with the immune system in these disorders.
The following article types will be accepted: Original Research, Clinical Trials, Reviews, Systematic reviews, Brief Research Reports, Case Reports, Mini-reviews, Perspectives, General commentaries, and Opinions. The following themes are welcome:
• Studies connecting the human virome in gastrointestinal, liver, and metabolic disorders
• Studies analyzing the human virome composition and functional variation among gastrointestinal, liver, and metabolic disorders
• Unravelling the role of the human virome in gastrointestinal, liver, and metabolic disorder etiology, physiology, and its response to medications and clinical procedures
• Studies connecting the human virome-immune homeostasis and regulation of the immune response in gastrointestinal, liver, and metabolic disorders
• Studies analyzing the human virome interventions, including fecal microbiota transplantation, diet, supplements, clinical trials, or therapies in gastrointestinal, liver, and metabolic disorders
Keywords:
human virome, gut virome, obesity, diabetes mellitus, immune response, pathogenesis, pathophysiology, mechanisms, gastrointestinal disease, liver disease, metabolic disorder, IBD, colorectal cancer, MASLD
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.