About this Research Topic
This Research Topic delves into the advances of 3D in vitro brain models, covering the outlook of fundamentals and principles of 3D brain models and exploring their potential to model early brain development, neural circuitry, neurodegeneration and regeneration, and neurological disorders. This Research Topic will give an overview of 3D brain models and their applications in neural development and diseases. We emphasize the transformative potential of 3D brain models in empowering neurological studies with their advantages in modeling the more sophisticated human brain. From decoding the establishment of 3D brain models to leveraging different models for downstream applications, this topic covers the latest advances, challenges, and future directions in the field. In this Research Topic, we welcome reviews from, but not limited to, the following topics:
- The fundamental, design factor, development, and characterization of 3D brain models with state-of-art techniques and their current limitations.
- Emerging trends and novel approaches in 3D brain model research; the current status of conventional spheroid and organoid models; the advancement of bioprinting-based neural tissue models.
- The advantage of 3D brain models in recapitulating functionality, neural circuits, biomimetic gradients, and modeling neurological disorders.
- The application of 3D brain models; the generation systems, cell types, materials, structures, and functionality of 3D brain models.
- The advantage of 3D brain models in disease modeling and drug screening.
- Clinical trials and real-world implementation of 3D brain models in neurological disorders; ethical and privacy concerns, and in vivo attempts for some 3D brain models.
- Summary of the current state of 3D brain models in design and functionality; promising prospects and potential application of 3D brain models in studying development and diseases.
Keywords: 3D bioprinting
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