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This Research Topic honors the memory of Dr. William E. Paul, a towering figure in immunology for many decades. Dr. William E. Paul (fondly known as Bill), led an extraordinary scientific legacy, matched only by his legacy of mentoring prowess.

This article collection, authored by many of Bill’s ...

This Research Topic honors the memory of Dr. William E. Paul, a towering figure in immunology for many decades. Dr. William E. Paul (fondly known as Bill), led an extraordinary scientific legacy, matched only by his legacy of mentoring prowess.

This article collection, authored by many of Bill’s trainees (or colleagues, as Bill would call them), will tribute the vast interests and expertise that have germinated within Bill’s lab, and now flower throughout the scientific and medical world. These articles will encompass basic, translational and clinical findings on subjects that were close to home for Bill Paul. These include the regulation of T-cell differentiation, immune homeostasis, and the effects and regulation of IL-4, along with research avenues that his individual trainees have now followed in their own unique paths.

This Research Topic is appropriately introduced by Bill’s beloved wife and life partner, Marilyn, who provides us all with a fuller memory of Bill, whose endless fascination with, and contributions to the world, were not limited to science. This tribute collection aims to enlighten readers of the state of the art in immunology and beyond and to remind the immunology community of the enormous impact Bill Paul has had in shaping the art, the artists and their respective work presented here.

In addition to invited articles from close colleagues of Bill, this Research Topic welcomes other reviews and original research articles in areas related to Bill’s research interests, including but not limited to: T-cell differentiation, immune homeostasis, and the effects and regulation of IL-4. Please submit an abstract prior to full manuscript submission to express your interest.

Keywords: Dr. William E. Paul, T-cell differentiation, immune homeostasis, IL-4


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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