Research Topic

Diabetes During and Beyond Pregnancy: A Life Course Perspective

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About this Research Topic

Diabetes in pregnancy, including gestational diabetes (GDM) and pre-existing diabetes, imposes significant and adverse influences on maternal health as well as fetal development and child health. In the mother, GDM usually resolves after pregnancy unless it represents previously undiagnosed type 2 diabetes ...

Diabetes in pregnancy, including gestational diabetes (GDM) and pre-existing diabetes, imposes significant and adverse influences on maternal health as well as fetal development and child health. In the mother, GDM usually resolves after pregnancy unless it represents previously undiagnosed type 2 diabetes which is first recognized during pregnancy. GDM is linked to substantially increased risk for developing type 2 diabetes and cardiovascular disorders. Despite the fact that GDM has been acknowledged as a subtype of diabetes for decades, appropriate cutoff points and procedures for screening and diagnosis are still under debate. Beyond the traditional use of insulin (basal-bolus or insulin pump therapy), oral hypoglycemic agents are introduced as new options in clinical management of GDM and pre-existing diabetes, but their impact on pregnancy outcomes and long-term health effects for both mothers and their offspring remains unclear. In recent years, the utility of omics techniques, such as genomics, epigenomics, proteomics, metabolomics, and microbiome, has advanced our knowledge on the etiology, prediction and “precision medicine” of gestational diabetes.

With this Research Topic, we aim to provide an updated overview of clinical and epidemiologic studies on diabetes and pregnancy from a life course perspective. We will welcome original research articles and review articles on, but not limited to, the following topics.
1. Epidemiology, risk factors for, and prevention of gestational diabetes;
2. Life course impact of gestational diabetes on cardiometabolic health after pregnancy;
3. Transgenerational effects of diabetes complicating pregnancy on the offspring;
4. Controversies of screening and diagnostic criteria for gestational diabetes and their long-term health impact in mother and child;
5. Comparative effectiveness research in clinical management of gestational diabetes and pregnancy complicated by pre-existing type 1 or type 2 diabetes;
6. Omics studies in the area of diabetes and pregnancy.

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