About this Research Topic
The goal of this Research Topic is to attract contributions aimed at shedding more light on the still debated relationship between atopy and cancer predisposition. Studies to date have documented negative or positive connections, or no connection at all. This might depend on several variables, including the populations and endpoints selected in association studies, specific phenotypes and endotypes of the atopic condition, the histology, genotype, immunogenicity, and location of primary or metastatic cancers, and the involvement of distinct innate and adaptive immune components and pathways.
All forms of contribution that are currently accepted by Frontiers in Allergy are welcome. Specific topics may include, but are not limited to, the following:
- The development of cancer in prospective or retrospective populations of patients with atopic conditions in different Countries or geographical areas
- The relative contribution of independent variables, e.g., environmental factors, hygiene status, socioeconomic conditions, and microbiota diversity and composition, to the development of cancer in atopic populations
- The relationship of biomarkers of atopy to the cancer histotype, genotype, grade, and/or stage
- The induction and/or detection of cancer antigen- and neoantigen-specific IgE, IgE-switched B cells and plasma blasts in preclinical and translational models
- The cells, factors, and signals that promote an IgE response within the tumour microenvironment
- The relative balance of specific and total IgE, including the IgE to IgG4 balance, in cancer development and progression and the phenotypes of tumour-infiltrating leucocytes
- The role of IgE-bearing cells, e.g., mast cells, basophils, and eosinophils, in tumour immunosurveillance and the regulation of their functions by immune checkpoints and tumour-delivered signals
- The mechanisms accounting for novel nonconventional functions of IgE in immune surveillance, including the promotion of cell-mediated cytotoxic responses
- The possible impact of treatments interfering with IgE function, eosinophil function, or the function of IgE-and eosinophil-promoting, type 2 cytokines, on cancer development and progression
All article types accepted by Frontiers are encouraged.
Keywords: Atopy, Allergic inflammation, Allergo-Oncology, Basophils, Eosinophils, IgE, IgE/IgG4 balance, IgE receptors, Mast cells, Tissue remodelling in asthma and atopy, Type 2 cytokines
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.