The aging population is growing at an unparalleled rate, and the incidence of allergic reactions is also rising worldwide. Several factors render the elderly susceptible to allergic disorders such as asthma, atopic dermatitis, and drug allergy, including the physiological changes of aging, a decline in barrier function, the skewing of adaptive immunity to a Th2 response, dysregulation of innate immune cells, and age-related changes of microbiota. Aging is accompanied by a progressive remodeling of immune system functions, leading to an increased pro-inflammatory status which named senescence-associated secretory phenotypes (SASPs).
Age-related changes in immune function can have a significant impact on allergic disorders. Due to the complex pathogenesis and multifactorial nature of elder allergic diseases, its treatment and control are still difficult. This Research Topic aims to address the relationship between ageing and allergy, new developments in pathogenesis, strategies for the prevention of the diseases, as well as new and future targeting treatments.
All manuscript types accepted by Frontiers are welcome. Suitable topics include but are not limited to:
General Studies of Senile Allergic Diseases
• Epidemiological studies on allergic diseases such as allergic rhinitis, asthma, atopic dermatitis, food allergy, drug allergy, etc. in the elderly within countries and regions
• Aging-related clinical characteristics in allergic diseases
Mechanisms of Senile Allergic Diseases
• The role and mechanisms of immunosenescence in the development of allergy march
• The role of senescence-related type 2 inflammation in allergic responses
• Changes in cell types and signaling pathways in specific tissues in senile allergic diseases
• Age-related oxidative stress in allergies
• Mechanisms of intrinsic and extrinsic aging from a barrier function perspective
• Mechanisms of photoaging in allergic dermatosis
• Epigenetic regulation of aging in allergic diseases
• Senescence-associated secretory phenotypes in allergic diseases
• Novel biomarkers for diagnosis and prediction of therapy responses in senile allergic diseases
Diagnosis and Treatment of Senile Allergic Diseases
• Strategies to control allergic diseases by delaying cellular senescence
• Mechanism of stem cell senescence and its application in the treatment of allergic diseases
Treatment challenges in allergic patients with multiple age-related diseases.
Keywords:
Aging, Allergic diseases, Senescence-associated secretory phenotype (SASP), Adverse reactions, Incidence, Pathogenesis, Dysfunction, Mechanism
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The aging population is growing at an unparalleled rate, and the incidence of allergic reactions is also rising worldwide. Several factors render the elderly susceptible to allergic disorders such as asthma, atopic dermatitis, and drug allergy, including the physiological changes of aging, a decline in barrier function, the skewing of adaptive immunity to a Th2 response, dysregulation of innate immune cells, and age-related changes of microbiota. Aging is accompanied by a progressive remodeling of immune system functions, leading to an increased pro-inflammatory status which named senescence-associated secretory phenotypes (SASPs).
Age-related changes in immune function can have a significant impact on allergic disorders. Due to the complex pathogenesis and multifactorial nature of elder allergic diseases, its treatment and control are still difficult. This Research Topic aims to address the relationship between ageing and allergy, new developments in pathogenesis, strategies for the prevention of the diseases, as well as new and future targeting treatments.
All manuscript types accepted by Frontiers are welcome. Suitable topics include but are not limited to:
General Studies of Senile Allergic Diseases
• Epidemiological studies on allergic diseases such as allergic rhinitis, asthma, atopic dermatitis, food allergy, drug allergy, etc. in the elderly within countries and regions
• Aging-related clinical characteristics in allergic diseases
Mechanisms of Senile Allergic Diseases
• The role and mechanisms of immunosenescence in the development of allergy march
• The role of senescence-related type 2 inflammation in allergic responses
• Changes in cell types and signaling pathways in specific tissues in senile allergic diseases
• Age-related oxidative stress in allergies
• Mechanisms of intrinsic and extrinsic aging from a barrier function perspective
• Mechanisms of photoaging in allergic dermatosis
• Epigenetic regulation of aging in allergic diseases
• Senescence-associated secretory phenotypes in allergic diseases
• Novel biomarkers for diagnosis and prediction of therapy responses in senile allergic diseases
Diagnosis and Treatment of Senile Allergic Diseases
• Strategies to control allergic diseases by delaying cellular senescence
• Mechanism of stem cell senescence and its application in the treatment of allergic diseases
Treatment challenges in allergic patients with multiple age-related diseases.
Keywords:
Aging, Allergic diseases, Senescence-associated secretory phenotype (SASP), Adverse reactions, Incidence, Pathogenesis, Dysfunction, Mechanism
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.