MicroRNAs (miRNAs) are small non-coding RNAs and approximately 22 nucleotides in length. miRNAs suppress expression of target mRNAs through their complementary base-paring (2-8 nucleotides), leading to translational repression and/or mRNA degradation. Main molecules that control miRNA biogenesis and function have been well established. Over the past 3 decades, about 2,600 mature miRNAs have been allocated to human genome and their target genes and roles in CNS homeostasis and pathophysiology have been intensively studied.
During the past decade or so, it has been increasingly clear that neuroinflammation plays fundamental roles in the development and progression of neurodegenerative diseases and stroke. Aging is a main risk factor of such diseases and characteristically associated with chronic, low-grade inflammation. Currently, although evidence supporting direct or indirect links between miRNAs and neuroinflammation in neurodegenerative diseases and aging is growing, their use and application for diagnosis and therapy are still uncertain.
The goal of this Research Topic is to investigate and offer new approaches and viewpoints on multifaceted roles of miRNAs in neuroinflammation and brain aging, aiming at mechanisms that control, particularly but not limited to, immune cell activation/polarization and homeostasis, metabolism, synaptic plasticity, neurogenesis, neuronal apoptosis and necrosis, cellular senescence, and circadian rhythm. Additionally, it is hoped that the articles covering this Research Topic will provide solid basis for developing new preventive, diagnostic and therapeutic means for neuroinflammation, neurodegenerative diseases, stroke and aging brain by modulating and monitoring miRNA expression.
This Research Topic accepts Original Research, Review and Mini-Review, and Perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Protective and/or pathogenic roles of miRNAs in neuroinflammation and neurodegenerative diseases
• Beneficial effects of exercise-induced miRNAs in neuroinflammation and brain health
• Mitochondrial miRNAs in neuroinflammation and metabolism
• miRNAs involved in neuronal necroptosis and apoptosis, and neuroinflammation
• miRNAs as biomarkers for neuroinflammation and neurological diseases
• miRNAs as aging biomarkers and as regulators of cellular senescence and lifespan
• miRNAs that regulate synaptic plasticity and neurogenesis by microglia
• Astrocytic miRNAs that regulate neuroinflammation and metabolism
• miRNAs associated with spinal cord injury and neural and axonal regeneration
• Progress and challenges in developing miRNAs as therapeutic and preventive agents in neuroinflammation, inflammageing and neurological diseases
The Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords:
microRNAs; neurodegenerative disease; neuroinflammation; immune cells; neurogenesis; aging; stroke, microRNAs, neurodegenerative disease, neuroinflammation, immune cells, neurogenesis, aging, stroke
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
MicroRNAs (miRNAs) are small non-coding RNAs and approximately 22 nucleotides in length. miRNAs suppress expression of target mRNAs through their complementary base-paring (2-8 nucleotides), leading to translational repression and/or mRNA degradation. Main molecules that control miRNA biogenesis and function have been well established. Over the past 3 decades, about 2,600 mature miRNAs have been allocated to human genome and their target genes and roles in CNS homeostasis and pathophysiology have been intensively studied.
During the past decade or so, it has been increasingly clear that neuroinflammation plays fundamental roles in the development and progression of neurodegenerative diseases and stroke. Aging is a main risk factor of such diseases and characteristically associated with chronic, low-grade inflammation. Currently, although evidence supporting direct or indirect links between miRNAs and neuroinflammation in neurodegenerative diseases and aging is growing, their use and application for diagnosis and therapy are still uncertain.
The goal of this Research Topic is to investigate and offer new approaches and viewpoints on multifaceted roles of miRNAs in neuroinflammation and brain aging, aiming at mechanisms that control, particularly but not limited to, immune cell activation/polarization and homeostasis, metabolism, synaptic plasticity, neurogenesis, neuronal apoptosis and necrosis, cellular senescence, and circadian rhythm. Additionally, it is hoped that the articles covering this Research Topic will provide solid basis for developing new preventive, diagnostic and therapeutic means for neuroinflammation, neurodegenerative diseases, stroke and aging brain by modulating and monitoring miRNA expression.
This Research Topic accepts Original Research, Review and Mini-Review, and Perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Protective and/or pathogenic roles of miRNAs in neuroinflammation and neurodegenerative diseases
• Beneficial effects of exercise-induced miRNAs in neuroinflammation and brain health
• Mitochondrial miRNAs in neuroinflammation and metabolism
• miRNAs involved in neuronal necroptosis and apoptosis, and neuroinflammation
• miRNAs as biomarkers for neuroinflammation and neurological diseases
• miRNAs as aging biomarkers and as regulators of cellular senescence and lifespan
• miRNAs that regulate synaptic plasticity and neurogenesis by microglia
• Astrocytic miRNAs that regulate neuroinflammation and metabolism
• miRNAs associated with spinal cord injury and neural and axonal regeneration
• Progress and challenges in developing miRNAs as therapeutic and preventive agents in neuroinflammation, inflammageing and neurological diseases
The Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords:
microRNAs; neurodegenerative disease; neuroinflammation; immune cells; neurogenesis; aging; stroke, microRNAs, neurodegenerative disease, neuroinflammation, immune cells, neurogenesis, aging, stroke
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.