Phytoconstituents, the bioactive compounds found in plants, have long been utilized in traditional medicine for their therapeutic properties. In recent years, there has been a growing interest in exploring the potential of phytoconstituents as adjuvants to modern synthetic drugs. The combination of phytoconstituents with synthetic drugs presents exciting therapeutic opportunities. Phytoconstituents can complement the actions of synthetic drugs, enhancing their efficacy, reducing toxicity, and broadening their spectrum of activity. This synergy allows for lower doses of synthetic drugs, minimizing adverse effects while maintaining therapeutic benefits. Moreover, phytoconstituents can offer unique modes of action not found in synthetic drugs alone. They often exhibit pleiotropic effects, targeting multiple molecular pathways and potentiating the therapeutic outcomes. This can be particularly beneficial in complex diseases where multi-target interventions are necessary.
The primary aim of this collection is to shed light on the possibilities and challenges associated with tapping into the inherent potential of natural compounds to enhance the efficacy of modern pharmacotherapy, ultimately propelling the field of integrative medicine forward.
This Research Topic welcomes original research articles and review articles focusing on, but not limited to, the following:
• The potential of phytoconstituents, sourced from plants and natural origins, in augmenting the efficacy and safety of modern synthetic drugs.
• The exploration of molecular mechanisms underlying the synergistic interactions between phytoconstituents and synthetic drugs. Article collection provide valuable insights into
• How integration can enhance therapeutic outcomes, such as inhibiting drug-metabolizing enzymes, agnostic or antagonistic at receptor sites
• Studies exploring multifaceted challenges linked to integrating phytoconstituents with modern synthetic medicine, such as standardization, quality control, quantification of pharmacological effects, complexities of pharmacokinetic & pharmacodynamic profiles assessment, mutual interaction at different levels, and complex regulatory landscape associated with these therapies.
Additionally, please note that all the manuscripts submitted to this project will be peer-reviewed and will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).
