Undoubtedly, nanoformulations have significant utility as drug delivery techniques. However, the current challenge is improving their optimization to ensure safety, efficacy, and scalability. This improvement is critical for enabling large-scale manufacturing and clinical adoption. Liposomes, solid lipid nanoparticles, and nanostructured lipid carriers have shown significant clinical efficacy in delivering hydrophobic and hydrophilic medicines. Lipid nanoparticles (LNP), on the other hand, have been acknowledged as a suitable carrier for nucleic acids such as DNA and mRNA, organ-specific targeting as well as exhibit excellent biocompatibility, biodegradability, and high entrapment efficacy. They are also extensively renowned for their non-toxic properties and ease of dose formulation. The use of lipid nanocarriers in pharmaceutical contexts is a new area of research that focuses on the transportation and administration of diverse therapeutic agents, such as biotechnological products and smaller therapeutic compounds.
The purpose of this title is to bring together a collection of investigations that demonstrate the potential of lipid nanoparticles for encapsulating a wide range of bioactive medicines, including proteins, peptides, and phytochemicals. This collection will emphasize the use of LNPs in a wide range of advanced therapeutic modalities, including cancer tissue targeting and therapy, lymphatic targeting, liver targeting, brain targeting, and others. Targeting through nanoparticles is a well-known prospective therapeutic method that can precisely target specific locations to treat diseases. Targeting a drug to a specific organ improve therapeutic effectiveness, reduce drug-related side effects especially in cancer patients, and reduce dose frequency. Using appropriate techniques, these LNPs can be designed to target specific cells and organs in the body via passive, active, and endogenous targeting processes.
We welcome the submission of manuscripts including, but not limited to, the following topics: Special focus will be given (but is not restricted) to:
● The present challenges, potential hazards, and adverse effects highlighting case studies associated with drugs in the context of Cancer therapy.
● The utilization of multifunctional lipid nanoparticles and lipids in the development of nano-therapeutic dosages.
● The production of ligand tethered lipid nanoparticles for the purpose of targeting specific carcinomas in organs.
● The utilization of bioengineered solid lipid nanoparticles an innovative approach in the field of hepatic cancer therapy.
● The utilization of lipid nanoparticles for the treatment of neurodegenerative disorders: A comprehensive approach.
● Exploring the strategies employed by lipid nanoparticles for the purpose of targeting the brain and their subsequent characterization.
● Radioimging techniques to trace nanoparticles in specific organ.
● A promising delivery of nucleic acid via solid lipid nanoparticles.
Priority will be given to the scientific study, clinical report, in-vivo experimental study, where lipid nanoparticles contributed for effective organ targeting.
Keywords:
Lipid nanoparticles, Cancer therapy, targeting the brain, organ targeting, Radioimging techniques, neurodegenerative disorders.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Undoubtedly, nanoformulations have significant utility as drug delivery techniques. However, the current challenge is improving their optimization to ensure safety, efficacy, and scalability. This improvement is critical for enabling large-scale manufacturing and clinical adoption. Liposomes, solid lipid nanoparticles, and nanostructured lipid carriers have shown significant clinical efficacy in delivering hydrophobic and hydrophilic medicines. Lipid nanoparticles (LNP), on the other hand, have been acknowledged as a suitable carrier for nucleic acids such as DNA and mRNA, organ-specific targeting as well as exhibit excellent biocompatibility, biodegradability, and high entrapment efficacy. They are also extensively renowned for their non-toxic properties and ease of dose formulation. The use of lipid nanocarriers in pharmaceutical contexts is a new area of research that focuses on the transportation and administration of diverse therapeutic agents, such as biotechnological products and smaller therapeutic compounds.
The purpose of this title is to bring together a collection of investigations that demonstrate the potential of lipid nanoparticles for encapsulating a wide range of bioactive medicines, including proteins, peptides, and phytochemicals. This collection will emphasize the use of LNPs in a wide range of advanced therapeutic modalities, including cancer tissue targeting and therapy, lymphatic targeting, liver targeting, brain targeting, and others. Targeting through nanoparticles is a well-known prospective therapeutic method that can precisely target specific locations to treat diseases. Targeting a drug to a specific organ improve therapeutic effectiveness, reduce drug-related side effects especially in cancer patients, and reduce dose frequency. Using appropriate techniques, these LNPs can be designed to target specific cells and organs in the body via passive, active, and endogenous targeting processes.
We welcome the submission of manuscripts including, but not limited to, the following topics: Special focus will be given (but is not restricted) to:
● The present challenges, potential hazards, and adverse effects highlighting case studies associated with drugs in the context of Cancer therapy.
● The utilization of multifunctional lipid nanoparticles and lipids in the development of nano-therapeutic dosages.
● The production of ligand tethered lipid nanoparticles for the purpose of targeting specific carcinomas in organs.
● The utilization of bioengineered solid lipid nanoparticles an innovative approach in the field of hepatic cancer therapy.
● The utilization of lipid nanoparticles for the treatment of neurodegenerative disorders: A comprehensive approach.
● Exploring the strategies employed by lipid nanoparticles for the purpose of targeting the brain and their subsequent characterization.
● Radioimging techniques to trace nanoparticles in specific organ.
● A promising delivery of nucleic acid via solid lipid nanoparticles.
Priority will be given to the scientific study, clinical report, in-vivo experimental study, where lipid nanoparticles contributed for effective organ targeting.
Keywords:
Lipid nanoparticles, Cancer therapy, targeting the brain, organ targeting, Radioimging techniques, neurodegenerative disorders.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.