Innate immune pathways are pivotal in driving anticancer response and regulating the tumour microenvironment, to favour tumour growth, leading to metastasis. Since the last decade, breakthrough research on exploring innate immune signalling and presenting these pathways as target for developing chemotherapeutic and immunotherapeutic intervention strategies, against human cancer. Hitherto, gut-associated cancer, head and neck cancer, blood cancers, etc. have been documented to be closely associated with the perturbation of innate immune signalling pathways.
Since their discovery, innate immune receptors have got immense attention amongst the researchers owing to their explicit role in regulation of human immune responses. Continuous research on the same has explored new domains, particularly in connection with various cancer subtypes. The growing importance of innate immune pathways as target of chemotherapy and/or immunotherapy prompted the editors to propose the topic. Such research topic and a comprehensive collection of the articles on the fundamental immunology of innate immune pathways in human cancers and therapeutic promises of these pathways for adopting appropriate intervention strategies will most likely provide a much-needed platform to the scientific communities throughout the globe.
The present Research Topic will address the recent developments in the field of innate immune signalling pathways related with protection and pathogenesis of human cancers. Technological developments/upgradation, new methodologies/protocols, developments of new knowledge and fundamentals, exploration of novel targets and/or therapeutics will likely bolster recent research in the field of interest of the research topic.
The Research Topic aims to present a comprehensive collection of articles on the immunobiological relevance of innate immune pathways in the context of pathogenesis of various human cancer subtypes and host immunity against cancer. In addition, therapeutic promises of innate signaling-directed chemo-and immunotherapeutic intervention of human cancers will also be included. Contributing authors are expected to add new dimension to the existing knowledge on the fundamental and therapeutic aspect of innate immune response pathways for generating/transferring knowledge. Original research articles and reviews are particularly welcome (but not limited) in the following themes:
• Exploration of basic biology/roles of innate immune pathways in human cancers
• Conception of novel therapeutic strategies for targeting the innate immune receptors and pathways
• Development of new tools and techniques
• Drug development and clinical trial of chemotherapeutics/immune-therapeutics for targeted intervention of human cancers
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Innate immune pathways are pivotal in driving anticancer response and regulating the tumour microenvironment, to favour tumour growth, leading to metastasis. Since the last decade, breakthrough research on exploring innate immune signalling and presenting these pathways as target for developing chemotherapeutic and immunotherapeutic intervention strategies, against human cancer. Hitherto, gut-associated cancer, head and neck cancer, blood cancers, etc. have been documented to be closely associated with the perturbation of innate immune signalling pathways.
Since their discovery, innate immune receptors have got immense attention amongst the researchers owing to their explicit role in regulation of human immune responses. Continuous research on the same has explored new domains, particularly in connection with various cancer subtypes. The growing importance of innate immune pathways as target of chemotherapy and/or immunotherapy prompted the editors to propose the topic. Such research topic and a comprehensive collection of the articles on the fundamental immunology of innate immune pathways in human cancers and therapeutic promises of these pathways for adopting appropriate intervention strategies will most likely provide a much-needed platform to the scientific communities throughout the globe.
The present Research Topic will address the recent developments in the field of innate immune signalling pathways related with protection and pathogenesis of human cancers. Technological developments/upgradation, new methodologies/protocols, developments of new knowledge and fundamentals, exploration of novel targets and/or therapeutics will likely bolster recent research in the field of interest of the research topic.
The Research Topic aims to present a comprehensive collection of articles on the immunobiological relevance of innate immune pathways in the context of pathogenesis of various human cancer subtypes and host immunity against cancer. In addition, therapeutic promises of innate signaling-directed chemo-and immunotherapeutic intervention of human cancers will also be included. Contributing authors are expected to add new dimension to the existing knowledge on the fundamental and therapeutic aspect of innate immune response pathways for generating/transferring knowledge. Original research articles and reviews are particularly welcome (but not limited) in the following themes:
• Exploration of basic biology/roles of innate immune pathways in human cancers
• Conception of novel therapeutic strategies for targeting the innate immune receptors and pathways
• Development of new tools and techniques
• Drug development and clinical trial of chemotherapeutics/immune-therapeutics for targeted intervention of human cancers
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.