Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) are two major forms of neurodegenerative disorders that contribute to cognitive decline and memory loss. Recent studies have highlighted the critical role of microglia, perivascular macrophages, and other immune cells in the pathogenesis of these diseases. Additionally, the involvement of blood-brain barrier (BBB) dysregulation, cerebrospinal fluid (CSF) flow disturbances, and neuroinflammation have been identified as key factors in the development and progression of AD and VCID.
Despite the growing understanding of these mechanisms, current treatments for these disorders are limited to symptom management, and causal therapeutic strategies have not yet been established. Furthermore, the complex etiology of AD and VCID, involving multiple environmental and genetic factors, necessitates a better investigation into potential diagnostic and therapeutic targets.
This research topic aims to advance our understanding of the cellular and molecular mechanisms underlying neurodegenerative diseases, particularly AD and VCID, and to identify novel therapeutic targets and strategies. The main objectives include elucidating the roles of microglia, perivascular macrophages, and other immune cells in disease pathogenesis, investigating the impact of BBB and CSF flow disturbances on disease progression, and exploring the potential of stem cell therapy and other innovative treatments for neurodegeneration.
To gather further insights into the pathophysiology and treatment of neurodegenerative diseases, we welcome articles addressing, but not limited to, the following themes:
- Microglial involvement in AD and VCID pathogenesis
- Roles of perivascular macrophages and other immune cells in neurodegeneration
- Blood-brain barrier dysregulation and cerebrospinal fluid flow disturbances in AD and VCID
- Neuroinflammation and its impact on disease progression
- Stem cell therapy and other innovative treatments for neurodegenerative diseases
- Genetic and environmental factors contributing to AD and VCID etiology
- Potential diagnostic and therapeutic targets for AD and VCID.
Keywords:
Alzheimer's, microglia, blood-brain barrier, neurodegeneration, stem cell therapy, macrophages
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) are two major forms of neurodegenerative disorders that contribute to cognitive decline and memory loss. Recent studies have highlighted the critical role of microglia, perivascular macrophages, and other immune cells in the pathogenesis of these diseases. Additionally, the involvement of blood-brain barrier (BBB) dysregulation, cerebrospinal fluid (CSF) flow disturbances, and neuroinflammation have been identified as key factors in the development and progression of AD and VCID.
Despite the growing understanding of these mechanisms, current treatments for these disorders are limited to symptom management, and causal therapeutic strategies have not yet been established. Furthermore, the complex etiology of AD and VCID, involving multiple environmental and genetic factors, necessitates a better investigation into potential diagnostic and therapeutic targets.
This research topic aims to advance our understanding of the cellular and molecular mechanisms underlying neurodegenerative diseases, particularly AD and VCID, and to identify novel therapeutic targets and strategies. The main objectives include elucidating the roles of microglia, perivascular macrophages, and other immune cells in disease pathogenesis, investigating the impact of BBB and CSF flow disturbances on disease progression, and exploring the potential of stem cell therapy and other innovative treatments for neurodegeneration.
To gather further insights into the pathophysiology and treatment of neurodegenerative diseases, we welcome articles addressing, but not limited to, the following themes:
- Microglial involvement in AD and VCID pathogenesis
- Roles of perivascular macrophages and other immune cells in neurodegeneration
- Blood-brain barrier dysregulation and cerebrospinal fluid flow disturbances in AD and VCID
- Neuroinflammation and its impact on disease progression
- Stem cell therapy and other innovative treatments for neurodegenerative diseases
- Genetic and environmental factors contributing to AD and VCID etiology
- Potential diagnostic and therapeutic targets for AD and VCID.
Keywords:
Alzheimer's, microglia, blood-brain barrier, neurodegeneration, stem cell therapy, macrophages
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.