Infectious diseases remain an important cause of morbidity and mortality globally, particularly in children under five of low-and middle-income countries (LMICs). Antimicrobial resistance (AMR) which is the ability of pathogens to sustain in an environment despite the presence of a drug that was previously used to kill or inhibit them, has been recognized as one of the foremost threats of the 21st century. AMR is a quintessential One Health issue affecting animal, human, and environmental health. By 2050, as many as 10 million people globally could be dying each year due to AMR. In 2019, AMR infections were associated with around 5 million deaths, among which 1.27 million were attributable to bacterial AMR. Sub-Saharan Africa suffered the highest burden of bacterial AMR with 27.3 deaths per 100,000 (20.9 – 35.3). Notwithstanding the growing body of evidence on the threat that AMR represents, considerable knowledge gaps remain regarding the risk factors, etiological diagnostic, treatment, prevention, and control measures of AMR in infectious diseases, especially in LMICs. The advent of genomics has the potential to assist in the (i) sustainable containment of bacterial AMR, (ii) design and development of vaccines, diagnostic tools, and alternatives to antibiotics, and (iii) aid in evidence-based decisions.
In this Research Topic, we wish to illustrate the importance of genetics and genomics in tackling AMR and infectious diseases in LMICs where these sciences are considerably needed for their sustainable management. Its goal is to bring in new genomic data that could enlarge the available literature on the burden, diagnosis, treatment, and prevention of AMR in infectious diseases in LMICs. Molecular epidemiology studies and innovative solutions applying genomics in AMR are of specific interest. Sociocultural, drug, and vaccine discovery, diagnostic development, and prevention measures can be addressed.
We wish to explore the status and future perspectives for a sustainable containment of AMR infections in LMICs. Applications of genomics for controlling AMR in infectious diseases caused by bacteria, viruses, fungi, and parasites are relevant to the Research Topic. The scope of the Research Topic is to bring new information on the use of genetics and genomics in the containment of AMR in infectious diseases.
This Research Topic will accept submissions of the following article types: Brief Research Reports, Clinical Trials, General Commentaries, Hypothesis & Theory, Methods, Mini Reviews, Opinion, Original Research, Perspectives, Reviews, Systematic Reviews, and Policy Paper. Specific topics to be addressed include, but are not limited to:
• Surveillance of AMR in infectious diseases at the animal, human, and environmental interfaces
• Antimicrobial resistance mechanisms and transmission
• Use of genomics for the development of diagnostic tools targeting AMR
• Genomics-based discovery of new antimicrobial drugs and vaccines
• New genomics approaches for prevention and control measures of AMR
• Genomic-based behavioral changes
• Evidence-based decisions to defeat AMR
Keywords:
antimicrobial resistant infectious diseases, low-income countries, middle-income countries, genetics, genomics, AMR, antimicrobial drugs
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Infectious diseases remain an important cause of morbidity and mortality globally, particularly in children under five of low-and middle-income countries (LMICs). Antimicrobial resistance (AMR) which is the ability of pathogens to sustain in an environment despite the presence of a drug that was previously used to kill or inhibit them, has been recognized as one of the foremost threats of the 21st century. AMR is a quintessential One Health issue affecting animal, human, and environmental health. By 2050, as many as 10 million people globally could be dying each year due to AMR. In 2019, AMR infections were associated with around 5 million deaths, among which 1.27 million were attributable to bacterial AMR. Sub-Saharan Africa suffered the highest burden of bacterial AMR with 27.3 deaths per 100,000 (20.9 – 35.3). Notwithstanding the growing body of evidence on the threat that AMR represents, considerable knowledge gaps remain regarding the risk factors, etiological diagnostic, treatment, prevention, and control measures of AMR in infectious diseases, especially in LMICs. The advent of genomics has the potential to assist in the (i) sustainable containment of bacterial AMR, (ii) design and development of vaccines, diagnostic tools, and alternatives to antibiotics, and (iii) aid in evidence-based decisions.
In this Research Topic, we wish to illustrate the importance of genetics and genomics in tackling AMR and infectious diseases in LMICs where these sciences are considerably needed for their sustainable management. Its goal is to bring in new genomic data that could enlarge the available literature on the burden, diagnosis, treatment, and prevention of AMR in infectious diseases in LMICs. Molecular epidemiology studies and innovative solutions applying genomics in AMR are of specific interest. Sociocultural, drug, and vaccine discovery, diagnostic development, and prevention measures can be addressed.
We wish to explore the status and future perspectives for a sustainable containment of AMR infections in LMICs. Applications of genomics for controlling AMR in infectious diseases caused by bacteria, viruses, fungi, and parasites are relevant to the Research Topic. The scope of the Research Topic is to bring new information on the use of genetics and genomics in the containment of AMR in infectious diseases.
This Research Topic will accept submissions of the following article types: Brief Research Reports, Clinical Trials, General Commentaries, Hypothesis & Theory, Methods, Mini Reviews, Opinion, Original Research, Perspectives, Reviews, Systematic Reviews, and Policy Paper. Specific topics to be addressed include, but are not limited to:
• Surveillance of AMR in infectious diseases at the animal, human, and environmental interfaces
• Antimicrobial resistance mechanisms and transmission
• Use of genomics for the development of diagnostic tools targeting AMR
• Genomics-based discovery of new antimicrobial drugs and vaccines
• New genomics approaches for prevention and control measures of AMR
• Genomic-based behavioral changes
• Evidence-based decisions to defeat AMR
Keywords:
antimicrobial resistant infectious diseases, low-income countries, middle-income countries, genetics, genomics, AMR, antimicrobial drugs
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.