Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the ability of the antioxidant defense mechanisms to neutralize them. This phenomenon is involved in both physiological and pathological processes. ROS are generated during normal cellular metabolism and in response to environmental stressors. When produced excessively, ROS can damage cellular component such as lipids, nucleic acids and proteins, leading to cellular dysfunction and the development of numerous diseases, among them neurogenerative disorders, aging, cancer and cardiovascular diseases. Both endogenous and exogenous antioxidants play a crucial role in counteracting oxidative stress by scavenging ROS and/or preventing their formation. This Research Topic aims to provide a comprehensive overview of the mechanisms underlying oxidative stress-induced cellular damage and the protective effects of antioxidants. This Research Topic is open, but not limited to, research relating to the following themes:• Sources and types of ROS and their biological effects on cellular components.• Molecular mechanisms underlying oxidative stress-induced damage, including lipid peroxidation, protein oxidation, DNA damage, and mitochondrial dysfunction.• Role of antioxidants in mitigating oxidative stress by scavenging ROS, enhancing antioxidant enzyme activity, and modulating signaling pathways involved in oxidative stress responses.• Therapeutic potential of antioxidants in preventing or ameliorating oxidative stress-related diseases, and aging-associated pathologies.• Role of oxidative stress in the pathogenesis of various infections, and potential of antioxidants to treat pathogens-induced oxidative stress.• Recent advancements in antioxidant research, including novel antioxidant compounds and delivery systems.We invite submissions of Original Research articles, Perspectives, Opinions, Reviews, and Mini Reviews focusing on new advancements, that contribute to the advancement of knowledge in the field of oxidative stress and antioxidants. This Research Topic will encompass findings from both in vitro and in vivo studies, including cell culture experiments, animal models, and clinical trials, to provide a comprehensive understanding of the complex interplay between oxidative stress and antioxidants in health and disease. Emphasis will be placed on elucidating the molecular mechanisms underlying antioxidant-mediated cytoprotection and their implications for the development of antioxidant-based therapeutics. Additionally, authors are encouraged to address current challenges and future directions in antioxidant research, such as optimizing antioxidant formulations for improved bioavailability and targeting specific cellular compartments or signaling pathways implicated in oxidative stress.
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the ability of the antioxidant defense mechanisms to neutralize them. This phenomenon is involved in both physiological and pathological processes. ROS are generated during normal cellular metabolism and in response to environmental stressors. When produced excessively, ROS can damage cellular component such as lipids, nucleic acids and proteins, leading to cellular dysfunction and the development of numerous diseases, among them neurogenerative disorders, aging, cancer and cardiovascular diseases. Both endogenous and exogenous antioxidants play a crucial role in counteracting oxidative stress by scavenging ROS and/or preventing their formation. This Research Topic aims to provide a comprehensive overview of the mechanisms underlying oxidative stress-induced cellular damage and the protective effects of antioxidants. This Research Topic is open, but not limited to, research relating to the following themes:• Sources and types of ROS and their biological effects on cellular components.• Molecular mechanisms underlying oxidative stress-induced damage, including lipid peroxidation, protein oxidation, DNA damage, and mitochondrial dysfunction.• Role of antioxidants in mitigating oxidative stress by scavenging ROS, enhancing antioxidant enzyme activity, and modulating signaling pathways involved in oxidative stress responses.• Therapeutic potential of antioxidants in preventing or ameliorating oxidative stress-related diseases, and aging-associated pathologies.• Role of oxidative stress in the pathogenesis of various infections, and potential of antioxidants to treat pathogens-induced oxidative stress.• Recent advancements in antioxidant research, including novel antioxidant compounds and delivery systems.We invite submissions of Original Research articles, Perspectives, Opinions, Reviews, and Mini Reviews focusing on new advancements, that contribute to the advancement of knowledge in the field of oxidative stress and antioxidants. This Research Topic will encompass findings from both in vitro and in vivo studies, including cell culture experiments, animal models, and clinical trials, to provide a comprehensive understanding of the complex interplay between oxidative stress and antioxidants in health and disease. Emphasis will be placed on elucidating the molecular mechanisms underlying antioxidant-mediated cytoprotection and their implications for the development of antioxidant-based therapeutics. Additionally, authors are encouraged to address current challenges and future directions in antioxidant research, such as optimizing antioxidant formulations for improved bioavailability and targeting specific cellular compartments or signaling pathways implicated in oxidative stress.