Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to proteins, dictating their fate from degradation to functional reorganization. This modification, catalyzed by a series of enzymes (E1, E2, E3), is crucial for maintaining cellular homeostasis and is highly involved in key processes such as signal transduction, DNA repair, and gene expression. Recent studies illustrate how ubiquitination dysfunction is linked to numerous diseases, highlighting its role in immune regulation, cancer progression, and other pathologies. However, despite significant advancements, the full mechanistic pathways and implications of ubiquitination in disease progression and immune system dysfunction remain incompletely understood.
This Research Topic aims to deepen the understanding of how ubiquitination influences disease development, progression, and response to therapies. By focusing on the modulation of cell signaling and immune responses through ubiquitination, our goal is to uncover new mechanistic insights that could lead to more effective therapeutic strategies. Essential objectives include elucidating the non-degradative roles of ubiquitination in immune cell function and tumor microenvironment modulation, exploring the potential of ubiquitination as a biomarker, and advancing our understanding of its molecular mechanisms in disease contexts.
To explore the broad implications of ubiquitination in health and disease, this topic sets boundaries on cellular and molecular studies, particularly within the immune system and cancer biology. We invite mini-reviews, systematic reviews, clinical trials, and original research articles covering, but not limited to, the following topics:
1. Explore the regulation of immune cell functions through ubiquitination in non-cancerous diseases, providing insights into how ubiquitination influences immune responses across various pathological conditions.
2. Investigate changes in ubiquitination processes within the tumor immune microenvironment and their implications for tumor progression, focusing on how ubiquitination mediates the complex interactions between tumor cells and the immune system.
3. Uncover new mechanisms involved in the regulation of ubiquitination processes, offering innovative perspectives on the molecular underpinnings of ubiquitin-mediated regulation in immunology.
4. Present the latest advancements in ubiquitination research, including novel discoveries that enhance our current understanding and open new avenues for investigation.
5. New drugs that target the ubiquitination pathway.
6. The potential utility of ubiquitination levels as biomarkers for disease diagnosis, immunotherapy response, and prognosis.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to proteins, dictating their fate from degradation to functional reorganization. This modification, catalyzed by a series of enzymes (E1, E2, E3), is crucial for maintaining cellular homeostasis and is highly involved in key processes such as signal transduction, DNA repair, and gene expression. Recent studies illustrate how ubiquitination dysfunction is linked to numerous diseases, highlighting its role in immune regulation, cancer progression, and other pathologies. However, despite significant advancements, the full mechanistic pathways and implications of ubiquitination in disease progression and immune system dysfunction remain incompletely understood.
This Research Topic aims to deepen the understanding of how ubiquitination influences disease development, progression, and response to therapies. By focusing on the modulation of cell signaling and immune responses through ubiquitination, our goal is to uncover new mechanistic insights that could lead to more effective therapeutic strategies. Essential objectives include elucidating the non-degradative roles of ubiquitination in immune cell function and tumor microenvironment modulation, exploring the potential of ubiquitination as a biomarker, and advancing our understanding of its molecular mechanisms in disease contexts.
To explore the broad implications of ubiquitination in health and disease, this topic sets boundaries on cellular and molecular studies, particularly within the immune system and cancer biology. We invite mini-reviews, systematic reviews, clinical trials, and original research articles covering, but not limited to, the following topics:
1. Explore the regulation of immune cell functions through ubiquitination in non-cancerous diseases, providing insights into how ubiquitination influences immune responses across various pathological conditions.
2. Investigate changes in ubiquitination processes within the tumor immune microenvironment and their implications for tumor progression, focusing on how ubiquitination mediates the complex interactions between tumor cells and the immune system.
3. Uncover new mechanisms involved in the regulation of ubiquitination processes, offering innovative perspectives on the molecular underpinnings of ubiquitin-mediated regulation in immunology.
4. Present the latest advancements in ubiquitination research, including novel discoveries that enhance our current understanding and open new avenues for investigation.
5. New drugs that target the ubiquitination pathway.
6. The potential utility of ubiquitination levels as biomarkers for disease diagnosis, immunotherapy response, and prognosis.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
