About this Research Topic
This Research Topic, entitled "Targeting Macrophages in Haematological Malignancies", explores the evolving landscape of targeting macrophages as a promising therapeutic approach and delves into the diverse strategies employed to harness the potential of macrophage-targeted therapies in haematological malignancies. It examines the dynamic roles of macrophages within the haematological tumour microenvironment, explores the latest advancements in developing novel therapeutic agents, such as small molecules, antibodies and immunotherapies that designed to modulate macrophage behaviour and enhance their anti-tumour activity. The collection investigates strategies for reprogramming macrophages towards a pro-inflammatory, anti-tumoral phenotype, with a focus on cytokine and chemokine modulation and considers the potential synergies and challenges of combining macrophage-targeted therapies with other established treatments, such as chemotherapy, radiation therapy and immunotherapies. The collection discusses the clinical utility of discovering biomarkers that can aid in patient stratification and guide tailored macrophage-targeted treatment approaches, and finally, it provides insights into the clinical trials and outcomes of therapies targeting macrophages in haematological malignancies, with an emphasis on safety, efficacy and patient quality of life.
This Research Topic aims to provide a comprehensive overview of the current state of research in the field while shedding light on the potential of macrophage-targeted therapies to revolutionize the management of haematological malignancies. It will provide researchers, clinicians and healthcare professionals valuable insights into the challenges and opportunities associated with this innovative approach, ultimately advancing our scientific understanding of these complex malignancies and enhancing therapy outcomes.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Macrophage, chemotherapy, cytokines, chemokine modulation, Haematological Malignancies
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