In regenerative medicine, autologous platelet concentrates, obtained from a patient’s peripheral blood, have shown remarkable regenerative capabilities in recent years. These concentrates, rich in growth factors such as PDGF, TGF-β1, FGF-2, VEGF, and BMP, alongside various cellular constituents, play a pivotal role in tissue engineering and cellular therapies. They are increasingly utilized in plastic and reconstructive surgery, particularly in dental, dermatological, and orthopedic treatments. Despite their documented clinical effectiveness in promoting tissue regeneration and cell differentiation, the precise molecular mechanisms that drive these processes are not completely understood, presenting a crucial area for deeper research.

Recent findings have demonstrated that PRF, CGF, and other factors activate cell signaling pathways involved in cell proliferation, differentiation, and extracellular matrix remodeling. Their cellular components are also believed to play a significant role, although further research is needed in this area. Additionally, studies indicate that platelet derivatives trigger similar cell signaling pathways, highlighting their potential as promising agents for advancing regenerative medicine and enhancing the healing process in surgical treatments.

This Research Topic aims to advance our understanding of the molecular mechanisms activated by Platelet-rich fibrin (PRF), Concentrated Growth Factor (CGF), and other platelet derivatives in regenerative medicine. By exploring the cellular and molecular underpinnings of their therapeutic effects, the research could potentially unlock new avenues for optimizing and enhancing regenerative treatments across various medical specialties.

To gather further insights into the regulatory mechanisms and therapeutic potentials of platelet derivatives, we welcome articles addressing, but not limited to, the following themes:

• Characterization of cellular components of platelet derivatives and their differentiation potential.
• Mechanisms involved in tissue regeneration mediated by CGF or other platelet derivatives.
• Modulation of activity or levels of transcription factors crucial for cell proliferation or differentiation post-CGF treatment.
• Applications of CGF in regenerative medical practices across different surgical disciplines.
• Utilization of platelet derivatives as bioscaffolds in the regeneration of hard tissues.

We accept different article types including Mini-Reviews, Brief Research Reports, and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.

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The Role of Platelet Derivatives in Regenerative Medicine