Cells encounter a spectrum of physiological and pathological challenges. To ensure their survival, cells deploy intricate mechanisms for self-protection and recovery. Numerous stressors, including both external and internal factors such as chemical, physical, and microbial stimuli, have the potential to damage intracellular macromolecules and organellar integrity, threatening survival. Detection of these alterations is essential for coordinating effective responses to cellular stresses and damage. The cellular protective response involves membrane compartments such as the autophagy-lysosome system, as well as membraneless compartments, such as stress granules. Metabolic signaling pathways, such as mTOR and AMPK, undergo rewiring to conserve energy and resources, prioritizing crucial cellular processes. Together, these mechanisms collectively alleviate stress and minimize damage, thereby maintaining cellular homeostasis. The ability of cells to survive is determined by a multitude of factors and is intricately linked to various human diseases, including cancer, neurodegenerative disorders, and viral infections. Thus, delving into the molecular mechanisms underlying cellular survival offers promising insights into numerous biological pathways and holds clinical significance.
The investigation of cellular survival strategies holds substantial importance across various aspects, including biosynthesis, signaling, inflammation, and metabolism. This recognition has motivated major efforts to elucidate the underlying mechanisms involved in sensing stress and damage and initiating protective responses in normal cells as well as their roles in disease contexts. There is significant interest in comprehending the underlying molecular and cellular mechanisms in coping with stress and damage, as well as the interplay among cellular signaling pathways and processes, with the goal of bringing insights into a wide range of biological phenomena and systems.
The scope of this Research Topic is to provide a set of advanced research that addresses significant gaps in our understanding of the molecular and cellular mechanisms underlying cell survival strategies and their pathological implications. This includes the mechanisms involved in safeguarding organellar integrity, restructuring cell signaling and processes, as well as, stress granule-mediated protection, all vital for cell survival. We encourage contributions covering a wide range of topics, including but not limited to the following:
• Cellular responses to organellar damage
• Remodelling of cell signaling and processes during stress and damage
• Stress granule formation and function
• Inter-organelle interaction and organization for cell survival
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