Tuberculosis and Malaria are two major infectious diseases caused by species belonging to Mycobacterium and Plasmodium, respectively and they are a major cause of morbidity and mortality worldwide. Eradication of Tuberculosis and Malaria has been a major mandate of World Health Organization. Widespread awareness and knowledge have helped to limit the spread of the diseases to some extent, but eradication is still a far-sighted goal.
One of the major hurdles in controlling these diseases is the ability of the infectious microbes to develop resistance against all available drugs and antibiotics. The development of resistance is a multifaceted process driven by environmental, genetic, and evolutionary factors. Therefore, understanding these mechanisms as well as identification of new drugs and drug targets are crucial for formulating strategies to combat resistance and preserve the efficacy of antimicrobial therapies.
With this research topic, we aim to assemble a collection of state-of the art research articles that bring novel insights into the mechanisms that contribute towards the development of drug resistance. We welcome the submission of Original Research, Review, Mini-Review, Opinion and Perspective articles covering, but not limited to, the following topics:
• Exploring role of genes and their mutations in the development of resistance.
• Insight into the role of biofilm formation in the development of resistance.
• Novel insight into the role of immune evasion in the development of resistance.
• Identification of novel druggable targets and drug molecules.
• Role of membrane proteins or transporters in drug resistance.
• Impact of drug resistance on the host-pathogen interactions.
• Updates on the mechanism of antibiotic action and resistance.
• Effect of environment and nutrients in the emergence of drug resistance.
• Epidemiological studies addressing concerns over increased drug resistance.
Keywords:
Drug resistance, Infectious diseases, Malaria, Tuberculosis, Plasmodium, Mycobacterium, drug, targets, Antimicrobial, Antibiotics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Tuberculosis and Malaria are two major infectious diseases caused by species belonging to Mycobacterium and Plasmodium, respectively and they are a major cause of morbidity and mortality worldwide. Eradication of Tuberculosis and Malaria has been a major mandate of World Health Organization. Widespread awareness and knowledge have helped to limit the spread of the diseases to some extent, but eradication is still a far-sighted goal.
One of the major hurdles in controlling these diseases is the ability of the infectious microbes to develop resistance against all available drugs and antibiotics. The development of resistance is a multifaceted process driven by environmental, genetic, and evolutionary factors. Therefore, understanding these mechanisms as well as identification of new drugs and drug targets are crucial for formulating strategies to combat resistance and preserve the efficacy of antimicrobial therapies.
With this research topic, we aim to assemble a collection of state-of the art research articles that bring novel insights into the mechanisms that contribute towards the development of drug resistance. We welcome the submission of Original Research, Review, Mini-Review, Opinion and Perspective articles covering, but not limited to, the following topics:
• Exploring role of genes and their mutations in the development of resistance.
• Insight into the role of biofilm formation in the development of resistance.
• Novel insight into the role of immune evasion in the development of resistance.
• Identification of novel druggable targets and drug molecules.
• Role of membrane proteins or transporters in drug resistance.
• Impact of drug resistance on the host-pathogen interactions.
• Updates on the mechanism of antibiotic action and resistance.
• Effect of environment and nutrients in the emergence of drug resistance.
• Epidemiological studies addressing concerns over increased drug resistance.
Keywords:
Drug resistance, Infectious diseases, Malaria, Tuberculosis, Plasmodium, Mycobacterium, drug, targets, Antimicrobial, Antibiotics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.