About this Research Topic
Cardiovascular disease is a complex pathological process with multiple mechanisms and links among mechanisms contributing to the disease. To cope much management often focuses a single drug on a single target which is frequently not entirely effective. Chinese medicine with a long traditional history extending more than 2000 years is a medical system that applies multiple ingredients to resolve a complex disease problems. Numerous compounded Chinese medicines have shown very desirable effects on cardiovascular disease in clinical use. For example, a number of studies over the past decades has revealed a positive protective and therapeutic effect of compounded Chinese medicines and their major ingredients on Ischemia reperfusion-induced microcirculatory dysfunction and tissue injury in the heart, brain, liver, intestine, and lungs. These compounded medications contain diverse bioactive components with demonstrated ability to target energy metabolism; possess antioxidant effects; inhibit inflammatory cytokine release; alter adhesion molecule expression in leukocytes, platelets, and vascular endothelial cells; and the protect against thrombosis, albumin leakage, and mast cell degranulation. This special issue will publish reviews on this field and welcomes original research articles with respect to the multi-targeting effect of compound Chinese medicines and their effective ingredients on cardiovascular disease. In addition, this research topic calls for reviews and new research that focus on effective strategies for integrating Chinese medical approaches and methods with western medical treatment. The goal of this research topic is to increase awareness of the importance of Chinese medicine and the need to effectively and scientifically integrate these traditional approaches with western medicine.
Keywords: Chinese medicine, ischemia and reperfusion injury, fibrosis, energy metabolism, oxidative stress