In recent years, the complex ecosystem surrounding cancer cells, known as the tumor microenvironment (TME), has become a focal point of extensive scientific inquiry. The TME is composed of various cellular components like fibroblasts and immune cells, as well as non-cellular elements such as the extracellular matrix and biochemical gradients. Research has increasingly centered on the dynamic interplay between epigenetic regulation and metabolic processes within the TME. Such interactions are pivotal in modulating gene expression thereby influencing cancer cells' invasiveness and resistance to therapies. However, despite progress, the intricate relationship between metabolic changes and epigenetic modulation in cancer remains insufficiently elucidated, revealing a significant gap in our comprehensive understanding.This Research Topic aims to advance the understanding of epigenetic influences and metabolic reprogramming within the TME. It seeks to stimulate both foundational and applied research that can lead to the development of novel, targeted anti-cancer therapies by leveraging insights into metabolism and epigenetic regulation. The ultimate goal is to enhance the effectiveness of cancer therapies and minimize their adverse effects through innovative approaches that exploit these complex biological networks.To enhance research coverage on this subject, we invite contributions that address a variety of themes within the context of the TME:o Regulation of epigenetic processes within the TME, including the roles of non-coding RNAs and protein post-translational modifications.o Exploration of epigenetic markers in the TME with diagnostic, prognostic, or therapeutic potential.o Metabolic processes in cancer cells and their surrounding supportive tissues.o Immunometabolism's role within the TME.o Adaptation strategies of metabolism in the TME.o Impacts of metabolic alterations on immune surveillance, immunotherapy, and cancer evasion.o Tumor-associated immune checkpoints mediated by metabolic regulation.o Development of novel therapies targeting metabolic and epigenomic pathways.o Investigation of new materials influencing tumor cell biology.Note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this research topic.
In recent years, the complex ecosystem surrounding cancer cells, known as the tumor microenvironment (TME), has become a focal point of extensive scientific inquiry. The TME is composed of various cellular components like fibroblasts and immune cells, as well as non-cellular elements such as the extracellular matrix and biochemical gradients. Research has increasingly centered on the dynamic interplay between epigenetic regulation and metabolic processes within the TME. Such interactions are pivotal in modulating gene expression thereby influencing cancer cells' invasiveness and resistance to therapies. However, despite progress, the intricate relationship between metabolic changes and epigenetic modulation in cancer remains insufficiently elucidated, revealing a significant gap in our comprehensive understanding.This Research Topic aims to advance the understanding of epigenetic influences and metabolic reprogramming within the TME. It seeks to stimulate both foundational and applied research that can lead to the development of novel, targeted anti-cancer therapies by leveraging insights into metabolism and epigenetic regulation. The ultimate goal is to enhance the effectiveness of cancer therapies and minimize their adverse effects through innovative approaches that exploit these complex biological networks.To enhance research coverage on this subject, we invite contributions that address a variety of themes within the context of the TME:o Regulation of epigenetic processes within the TME, including the roles of non-coding RNAs and protein post-translational modifications.o Exploration of epigenetic markers in the TME with diagnostic, prognostic, or therapeutic potential.o Metabolic processes in cancer cells and their surrounding supportive tissues.o Immunometabolism's role within the TME.o Adaptation strategies of metabolism in the TME.o Impacts of metabolic alterations on immune surveillance, immunotherapy, and cancer evasion.o Tumor-associated immune checkpoints mediated by metabolic regulation.o Development of novel therapies targeting metabolic and epigenomic pathways.o Investigation of new materials influencing tumor cell biology.Note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this research topic.