Cancer immunotherapy, a pivotal shift in combating cancer, harnesses the immune system to target malignant cells. Although it has achieved remarkable successes, the response variability among patients highlights the critical need for novel therapeutic strategies. Recent explorations have spotlighted several alternative cell death pathways—necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and immunogenic cell death (ICD). These pathways play vital roles in the eradication of cancer cells and the enhancement of immune responses, presenting an urgent need to deepen our understanding of how they specifically contribute to and can revolutionize cancer immunotherapy.This Research Topic aims to systematically explore the individual roles of these distinct cell death pathways in the context of cancer immunotherapy. The goal is to uncover how these mechanisms interact with current cancer treatments and identify new potential intervention points. By detailing the interactions and potential synergies between these pathways and the immune system, this topic seeks to discover new therapeutic targets that could significantly improve the efficacy of immunotherapies.To expand our comprehension of the synergistic impact of cell death pathways on cancer immunotherapy, we welcome articles focusing on, but not limited to, the following themes:Molecular mechanisms underlying necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy.Impact of these cell death pathways on tumor progression and immune evasion.Characterizing functional compounds from natural products targeting these pathways.Pharmacological mechanisms of natural products influencing these cell death pathways.Crosstalk between cell death pathways and the immune system.Modulation of the tumor microenvironment by these cell death mechanisms.Development of precision immunotherapies focusing on these pathways.We encourage the submission of original research articles, reviews, mini-reviews, and perspective pieces that can contribute to broadening our understanding and development of more effective cancer therapies.
Cancer immunotherapy, a pivotal shift in combating cancer, harnesses the immune system to target malignant cells. Although it has achieved remarkable successes, the response variability among patients highlights the critical need for novel therapeutic strategies. Recent explorations have spotlighted several alternative cell death pathways—necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and immunogenic cell death (ICD). These pathways play vital roles in the eradication of cancer cells and the enhancement of immune responses, presenting an urgent need to deepen our understanding of how they specifically contribute to and can revolutionize cancer immunotherapy.This Research Topic aims to systematically explore the individual roles of these distinct cell death pathways in the context of cancer immunotherapy. The goal is to uncover how these mechanisms interact with current cancer treatments and identify new potential intervention points. By detailing the interactions and potential synergies between these pathways and the immune system, this topic seeks to discover new therapeutic targets that could significantly improve the efficacy of immunotherapies.To expand our comprehension of the synergistic impact of cell death pathways on cancer immunotherapy, we welcome articles focusing on, but not limited to, the following themes:Molecular mechanisms underlying necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy.Impact of these cell death pathways on tumor progression and immune evasion.Characterizing functional compounds from natural products targeting these pathways.Pharmacological mechanisms of natural products influencing these cell death pathways.Crosstalk between cell death pathways and the immune system.Modulation of the tumor microenvironment by these cell death mechanisms.Development of precision immunotherapies focusing on these pathways.We encourage the submission of original research articles, reviews, mini-reviews, and perspective pieces that can contribute to broadening our understanding and development of more effective cancer therapies.