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Addiction is a complex and multifaceted condition that encompasses physiological, psychological, and environmental factors. Advancements in human neuroscience have begun to unravel the intricate neural mechanisms underlying addictive behaviors. These insights are crucial for developing effective treatment strategies. This Research Topic seeks to explore the latest findings in the neuroscience of addiction, focusing on the neurobiological underpinnings and their implications for treatment and rehabilitation.

The primary goal of this Research Topic is to address the pressing need for an in-depth understanding of the neurobiological processes involved in addiction. Despite significant progress, addiction continues to pose a formidable challenge to healthcare systems globally. By fostering a comprehensive collection of research, we aim to bridge the gap between neuroscientific discoveries and practical treatment applications. Potential solutions lie in translating these neural insights into innovative interventions and therapies. Our objective is to assemble contributions that not only elucidate the neural circuitry and molecular pathways implicated in addiction but also propose novel, evidence-based treatment approaches that can be implemented in clinical settings.

We encourage the submission of diverse manuscript types, including original research articles, review articles, brief research reports, and opinion pieces. By compiling a multifaceted array of contributions, this Research Topic aims to advance the scientific understanding of addiction and promote the development of effective, neuroscience-informed treatment strategies.

We invite researchers to contribute original research articles, reviews, and theoretical papers that focus on the following themes:

Neural circuitry and neurotransmitter systems involved in addictive behaviors.

Genetic and epigenetic factors influencing susceptibility to addiction.

Advances in neuroimaging techniques to study addiction in humans.

The role of neuroplasticity in both the development of addiction and recovery processes.

Neurobiological effects of various substances of abuse, including but not limited to alcohol, opioids, stimulants, and nicotine.

Interactions between environmental stressors and neural mechanisms in addiction.

Cognitive and behavioral neuroscience approaches to understanding addiction.

Translation of neuroscientific findings into clinical practices, including pharmacological, behavioral, and neuromodulation therapies.

Sex differences in neural correlates of addiction

Neural changes due to addiction across the lifespan

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Neuroscience of addiction: Bridging neurobiological insights with treatment innovations Volume II